Evidence map›Paper›PMID 37953944›Full record

ArticleiScience2023

Amnion responses to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque.

Pietro Presicce, Monica Cappelletti, Marco Morselli, Feiyang Ma, Paranthaman Senthamaraikannan, Giulia Protti, Brian B Nadel, Laila Aryan, Mansoureh Eghbali, Lukasz Salwinski and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Evidence for Maternal Autoantibodies in the Pathogenesis of Preterm Birth.medRxiv : the preprint server for health sciences · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Pietro PresicceDivisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Monica CappellettiDivisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Marco MorselliDepartment of Molecular, Cell and Developmental Biology Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Feiyang MaDepartment of Molecular, Cell and Developmental Biology Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Paranthaman SenthamaraikannanDivision of Neonatology/Pulmonary Biology, Cincinnati Children's Hospital Research Foundation, The University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Giulia ProttiInstitute for Quantitative and Computational Biosciences - Collaboratory at the University of California Los Angeles, Los Angeles, CA, USA.
Brian B NadelDepartment of Molecular Cellular and Developmental Biology, and Institute for Genomics and Proteomics, University of California Los Angeles, Los Angeles, CA, USA.
Laila AryanDivision of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Mansoureh EghbaliDivision of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Lukasz SalwinskiUCLA-DOE Institute of Genomics and Proteomics, University of California Los Angeles, Los Angeles, CA, USA.
Neema PithiaDivisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Emily De FrancoDepartment of Obstetrics/Gynecology, Maternal-Fetal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Lisa A MillerDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, CA, USA.
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Alan H JobeDivision of Neonatology/Pulmonary Biology, Cincinnati Children's Hospital Research Foundation, The University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Claire A ChougnetDivision of Immunobiology, Cincinnati Children's Hospital Research Foundation, and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Suhas G KallapurDivisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity of California, Davis · USUniversity of Cincinnati · USUniversity of Cincinnati Medical Center · USQB3 · USQuantitative BioSciences · USUniversity of Milano-Bicocca · IT

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Transcriptomics and biomarkers of fetal neuroinflammationR01HD098389 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KALLAPUR, SUHAS · 2019 to 2023
$3.8M
Training CoreTL1DK132768 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2021 to 2026
$3.4M
Prenatal inflammatory exposures and neonatal immune developmentU01ES029234 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CHOUGNET, CLAIRE A. · 2017 to 2021
$2.7M
NICHD NIH HHS R01 HD098389NIDDK NIH HHS TL1 DK132768NIEHS NIH HHS U01 ES029234NIH HHS P51 OD011107
6 · The paper itself

Abstract

Intrauterine infection/inflammation (IUI) is a frequent complication of pregnancy leading to preterm labor and fetal inflammation. How inflammation is modulated at the maternal-fetal interface is unresolved. We compared transcriptomics of amnion (a fetal tissue in contact with amniotic fluid) in a preterm Rhesus macaque model of IUI induced by lipopolysaccharide with human cohorts of chorioamnionitis. Bulk RNA sequencing (RNA-seq) amnion transcriptomic profiles were remarkably similar in both Rhesus and human subjects and revealed that induction of key labor-mediating genes such as

Indexed as

BioinformaticsImmunologyOmics

Identifiers

PMID37953944
PMCPMC10637919
OpenAlexW4387409448

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.