Evidence map›Paper›PMID 37958843›Full record

ReviewInternational journal of molecular sciences2023

Deep Learning for Genomics: From Early Neural Nets to Modern Large Language Models.

Tianwei Yue, Yuanxin Wang, Longxiang Zhang, Chunming Gu, Haoru Xue, Wenping Wang, Qi Lyu, Yujie Dun

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Detecting Uniformity Artifacts in Ultrasound Transducers: Insights from Clinical Median Images and Deep Learning for Automatic Detection.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Harnessing interpretable deep learning to predict resistance inFrontiers in cellular and infection microbiology · 2026
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. RNA Large Language Models in Virology.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. ProPr54 web server: predicting σNAR genomics and bioinformatics · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tianwei YueSchool of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Yuanxin WangSchool of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Longxiang ZhangSchool of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0009-0009-0111-832X
Chunming GuDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0003-3568-2032
Haoru XueThe Robotics Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Wenping WangSchool of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0001-9665-3783
Qi LyuDepartment of Computational Mathematics, Science, and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Yujie DunSchool of Information and Communications Engineering, Xi'an Jiaotong University, Xi'an 710049, China.ORCID 0000-0001-5213-1000

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The data explosion driven by advancements in genomic research, such as high-throughput sequencing techniques, is constantly challenging conventional methods used in genomics. In parallel with the urgent demand for robust algorithms, deep learning has succeeded in various fields such as vision, speech, and text processing. Yet genomics entails unique challenges to deep learning, since we expect a superhuman intelligence that explores beyond our knowledge to interpret the genome from deep learning. A powerful deep learning model should rely on the insightful utilization of task-specific knowledge. In this paper, we briefly discuss the strengths of different deep learning models from a genomic perspective so as to fit each particular task with proper deep learning-based architecture, and we remark on practical considerations of developing deep learning architectures for genomics. We also provide a concise review of deep learning applications in various aspects of genomic research and point out current challenges and potential research directions for future genomics applications. We believe the collaborative use of ever-growing diverse data and the fast iteration of deep learning models will continue to contribute to the future of genomics.

Indexed as

Deep LearningAlgorithmsGenomicsIntelligenceLanguagecomputer visiondeep learninggenomicslarge language modelmulti-modal machine learning

Identifiers

PMID37958843
PMCPMC10649223

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.