Evidence map›Paper›PMID 37960878›Full record

ArticleACS chemical biology2023

Incorporation of Aliphatic Proline Residues into Recombinantly Produced Insulin.

Stephanie L Breunig, Janine C Quijano, Cecile Donohue, Amy Henrickson, Borries Demeler, Hsun Teresa Ku, David A Tirrell

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Stephanie L BreunigDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0002-8665-6363
Janine C QuijanoDepartment of Translational Research and Cellular Therapeutics, Diabetes and Metabolism Research Institute, Beckman Institute City of Hope, Duarte, California 91010, United States.
Cecile DonohueDepartment of Translational Research and Cellular Therapeutics, Diabetes and Metabolism Research Institute, Beckman Institute City of Hope, Duarte, California 91010, United States.
Amy HenricksonDepartment of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada.ORCID 0000-0003-3266-5202
Borries DemelerDepartment of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada.ORCID 0000-0002-2414-9518
Hsun Teresa KuDepartment of Translational Research and Cellular Therapeutics, Diabetes and Metabolism Research Institute, Beckman Institute City of Hope, Duarte, California 91010, United States.ORCID 0000-0001-5662-9893
David A TirrellDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0003-3175-4596
City of Hope · USCalifornia Institute of Technology · USUniversity of Lethbridge · CA

Funding

Development of an UltraScan Meta-Scheduler for HPC Job SubmissionR01GM120600 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Emre H. Brookes, BORRIES DEMELER · 2016 to 2026
$3.6M
Non-canonical amino acid mutagenesis in the engineering of insulin biophysicsR01GM134013 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI TIRRELL, DAVID A · 2019 to 2021
$913k
NIGMS NIH HHS R01 GM120600NIGMS NIH HHS R01 GM134013
6 · The paper itself

Abstract

Analogs of proline can be used to expand the chemical space about the residue while maintaining its uniquely restricted conformational space. Here, we demonstrate the incorporation of 4

Indexed as

InsulinProlineAmino AcidsEscherichia coliModels, MolecularMolecular ConformationAmino AcidsInsulinProline

Identifiers

PMID37960878
PMCPMC10728891
OpenAlexW4388667772

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.