Evidence map›Paper›PMID 37960979›Full record

ReviewAging cell2023

Latent transforming growth factor beta binding protein 4: A regulator of mitochondrial function in acute kidney injury.

Kit Neikirk, Adaku C Ume, Praveena Prasad, Andrea G Marshall, Jananie Rockwood, Tara-Yesomi Wenegieme, Kelia E McMichael, Melanie R McReynolds, Clintoria R Williams, Antentor Hinton

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kit NeikirkDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Adaku C UmeDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, Ohio, USA.
Praveena PrasadDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Andrea G MarshallDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Jananie RockwoodDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, Ohio, USA.
Tara-Yesomi WenegiemeDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, Ohio, USA.
Kelia E McMichaelDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, Ohio, USA.
Melanie R McReynoldsDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Clintoria R WilliamsDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, Ohio, USA.
Antentor HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-7730-952X
Wright State University · USVanderbilt University · USPennsylvania State University · US

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
PRIDE: Functional and Translational Genomics of Blood DisordersR25HL106365 · NHLBI · AUGUSTA UNIVERSITY · PI PACE, BETTY SUE · 2010 to 2024
$5.2M
Mechanisms of the Renoprotective Properties of Zinc Supplementation in Mouse Models of Chronic Kidney DiseaseR01DK133698 · NIDDK · WRIGHT STATE UNIVERSITY · PI WILLIAMS, CLINTORIA RICHARDS · 2022 to 2025
$1.9M
The role of NFkB in calcineurin inhibitor-induced renal fibrosisF30DK130531 · NIDDK · WRIGHT STATE UNIVERSITY · PI UME, ADAKU · 2022 to 2024
$143k
NHLBI NIH HHS R25 HL106365NIDDK NIH HHS F30 DK130531NIDDK NIH HHS P30 DK020593NIDDK NIH HHS R01 DK133698NIH HHS 5F30DK130531NIH HHS 5R01DK133698NIH HHS 5R25HL106365-12
6 · The paper itself

Abstract

Recently, latent transforming growth factor beta binding protein 4 (LTBP4) was implicated in the pathogenesis of renal damage through its modulation of mitochondrial dynamics. The seminal article written by Su et al. entitled "LTBP4 (Latent Transforming Growth Factor Beta Binding Protein 4) Protects Against Renal Fibrosis via Mitochondrial and Vascular Impacts" uncovers LTBP4's renoprotective role against acute kidney injury via modulating mitochondrial dynamics. Recently, LTBP4 has emerged as a driver in the mitochondrial-dependent modulation of age-related organ pathologies. This article aims to expand our understanding of LTBP4's diverse roles in these diseases in the context of these recent findings.

Indexed as

Acute Kidney InjuryHumansKidneyLatent TGF-beta Binding ProteinsMitochondriaTransforming Growth Factor betaLatent TGF-beta Binding ProteinsTransforming Growth Factor betaAgingAKIKidneyLTBP4mitochondria

Identifiers

PMID37960979
PMCPMC10726861
OpenAlexW4388669171

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.