Evidence map›Paper›PMID 37961498›Full record

ArticlemedRxiv : the preprint server for health sciences2023

A Massively Parallel Screen of 5'UTR Mutations Identifies Variants Impacting Translation and Protein Production in Neurodevelopmental Disorder Genes.

Stephen P Plassmeyer, Colin P Florian, Michael J Kasper, Rebecca Chase, Shayna Mueller, Yating Liu, Kelli McFarland White, Courtney F Jungers, Slavica Pavlovic Djuranovic, Sergej Djuranovic and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 12 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Stephen P PlassmeyerDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8986-0650
Colin P FlorianDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-6309-5199
Michael J KasperDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0008-0353-3087
Rebecca ChaseDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-8178-289X
Shayna MuellerDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0006-9950-9537
Yating LiuDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kelli McFarland WhiteDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Courtney F JungersDepartment of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Slavica Pavlovic DjuranovicDepartment of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sergej DjuranovicDepartment of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-9417-0822
Joseph D DoughertyDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6385-3997
Washington University in St. Louis · US

Funding

WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
HIGHLY PARALLEL ANALYSIS OF 5' AND 3' UTR VARIANTS IN NEURODEVELOPMENTAL DISORDERSR01MH116999 · NIMH · WASHINGTON UNIVERSITY · PI JOSEPH D DOUGHERTY · 2018 to 2026
$5.1M
MECHANISMS FOR MODULATION OF MIRNA-MEDIATED GENE SILENCINGR01GM112824 · NIGMS · WASHINGTON UNIVERSITY · PI DJURANOVIC, SERGEJ · 2015 to 2023
$3.1M
Dissecting mRNA-ribosome interaction in AU-rich transcriptome of Plasmodium falciparumR01GM136823 · NIGMS · WASHINGTON UNIVERSITY · PI DJURANOVIC, SERGEJ · 2021 to 2024
$1.4M
NICHD NIH HHS P50 HD103525NIGMS NIH HHS R01 GM112824NIGMS NIH HHS R01 GM136823NIMH NIH HHS R01 MH116999
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID37961498
PMCPMC10635273
OpenAlexW4388313945

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.