Evidence map›Paper›PMID 37961525›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Cross-sectional associations between prenatal maternal per- and poly-fluoroalkyl substances and bioactive lipids in three Environmental influences on Child Health Outcomes (ECHO) cohorts.

Himal Suthar, Tomás Manea, Dominic Pak, Megan Woodbury, Stephanie M Eick, Amber Cathey, Deborah J Watkins, Rita S Strakovsky, Brad A Ryva, Subramaniam Pennathur and 22 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 12 institutions in 2 countries.

Himal SutharDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Tomás ManeaDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Dominic PakDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Megan WoodburyDepartment of Civil and Environmental Engineering, Northeastern University, Boston, MA, USA.
Stephanie M EickGangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Amber CatheyDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Deborah J WatkinsDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Rita S StrakovskyInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.
Brad A RyvaInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.
Subramaniam PennathurDepartment of Internal Medicine-Nephrology, University of Michigan, Ann Arbor, MI, USA.
Lixia ZengDepartment of Internal Medicine-Nephrology, University of Michigan, Ann Arbor, MI, USA.
David WellerNSF International, Ann Arbor, MI, USA.
June-Soo ParkEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA, USA.
Sabrina SmithEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA, USA.
Erin DeMiccoProgram on Reproductive Health and the Environment, University of California, San Francisco, San Francisco, CA, USA.
Amy PadulaProgram on Reproductive Health and the Environment, University of California, San Francisco, San Francisco, CA, USA.
Rebecca C FryDepartment of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, Gillings School of Global Public Health, Chapel Hill, NC, USA.
Bhramar MukherjeeDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Andrea AguiarBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Illinois, USA.
Sarah Dee GeigerDepartment of Comparative Biosciences, University of Illinois Urbana-Champaign, IL, USA.
Shukhan NgDepartment of Comparative Biosciences, University of Illinois Urbana-Champaign, IL, USA.
Gredia Huerta-MontanezDepartment of Civil and Environmental Engineering, Northeastern University, Boston, MA, USA.
Carmen Vélez-VegaDepartment of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia, USA.
Zaira RosarioUniversity of Puerto Rico Graduate School of Public Health, San Juan, PR, USA.
Jose F CorderoDepartment of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia, USA.
Emily ZimmermanDepartment of Communication Sciences and Disorders, Northeastern University, Boston, MA, USA.
Tracey J WoodruffProgram on Reproductive Health and the Environment, University of California, San Francisco, San Francisco, CA, USA.
Rachel Morello-FroschProgram on Reproductive Health and the Environment, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1153-7287
Susan L SchantzBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Illinois, USA.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Akram AlshawabkehDepartment of Civil and Environmental Engineering, Northeastern University, Boston, MA, USA.
Max T AungDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
University of Michigan · USNortheastern University · USUniversity of California, San Francisco · USUniversity of Illinois Urbana-Champaign · USUniversity of Southern California · USCalifornia Environmental Protection Agency · USMichigan State University · USUniversity of Georgia · USEmory University · USNational Sanitation Foundation International · USUniversity of North Carolina at Chapel Hill · USUniversity of Puerto Rico System · PR

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI JUNFENG ZHANG · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7M
Research Experiences and Training Coordination CoreP42ES017198 · NIEHS · NORTHEASTERN UNIVERSITY · PI HARRIS, SEAN M · 2010 to 2024
$38.6M
Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)UH3OD023251 · OD · NORTHEASTERN UNIVERSITY · PI Akram N Alshawabkeh · 2018 to 2026
$24.0M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUH3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Andrea Aguiar, Susan L Schantz · 2018 to 2026
$18.6M
UCSF Environmental Research and Translation for Health Center (EaRTH Center)P30ES030284 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rashmi Joglekar · 2020 to 2026
$11.2M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUG3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SCHANTZ, SUSAN L · 2016 to 2024
$7.2M
NIDDK NIH HHS P30 DK089503NIEHS NIH HHS P01 ES022841NIEHS NIH HHS P01 ES022848NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P30 ES019776NIEHS NIH HHS P30 ES030284NIEHS NIH HHS P42 ES017198NIEHS NIH HHS P50 ES026049NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U2C OD023375NIH HHS UG3 OD023272NIH HHS UH3 OD023251NIH HHS UH3 OD023272
6 · The paper itself

Abstract

Background: Per- and poly-fluoroalkyl substances (PFAS) exposure can occur through ingestion of contaminated food and water, and inhalation of indoor air contaminated with these chemicals from consumer and industrial products. Prenatal PFAS exposures may confer risk for pregnancy-related outcomes such as hypertensive and metabolic disorders, preterm birth, and impaired fetal development through intermediate metabolic and inflammation pathways. Objective: Estimate associations between maternal pregnancy PFAS exposure (individually and as a mixture) and bioactive lipids. Methods: Our study included pregnant women in the Environmental influences on Child Health Outcomes Program: Chemicals in our Bodies cohort (CiOB, n=73), Illinois Kids Developmental Study (IKIDS, n=287), and the ECHO-PROTECT cohort (n=54). We measured twelve PFAS in serum and 50 plasma bioactive lipids (parent fatty acids and eicosanoids derived from cytochrome p450, lipoxygenase, and cyclooxygenase) during pregnancy (median 17 gestational weeks). Pairwise associations across cohorts were estimated using linear mixed models and meta-analysis. Associations between the PFAS mixture and individual bioactive lipids were estimated using quantile g-computation. Results: PFDeA, PFOA, and PFUdA were associated ( Conclusions: Bioactive lipids were revealed as biomarkers of PFAS exposure and could provide mechanistic insights into PFAS' influence on pregnancy outcomes, informing more precise risk estimation and prevention strategies.

Indexed as

Bioactive lipidsEicosanoidsMixturesPFAS

Identifiers

PMID37961525
PMCPMC10635258
OpenAlexW4388331319

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.