Evidence map›Paper›PMID 37961539›Full record

ArticlebioRxiv : the preprint server for biology2025

A Latent Activated Olfactory Stem Cell State Revealed by Single-Cell Transcriptomic and Epigenomic Profiling.

Koen Van den Berge, Dana Bakalar, Hsin-Jung Chou, Divya Kunda, Davide Risso, Kelly Street, Elizabeth Purdom, Sandrine Dudoit, John Ngai, Whitney Heavner

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Koen Van den BergeDepartment of Statistics, University of California, Berkeley, CA.ORCID 0000-0002-1833-8478
Dana BakalarMolecular Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-8257-4427
Hsin-Jung ChouDepartment of Molecular and Cell Biology, University of California, Berkeley, CA.
Divya KundaMolecular Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-6949-8172
Davide RissoDepartment of Statistical Sciences, University of Padova, Padova, Italy.ORCID 0000-0001-8508-5012
Kelly StreetDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.ORCID 0000-0001-6379-5013
Elizabeth PurdomDepartment of Statistics, University of California, Berkeley, CA.ORCID 0000-0001-9455-7990
Sandrine DudoitDepartment of Statistics, University of California, Berkeley, CA.ORCID 0000-0002-6069-8629
John NgaiMolecular Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-1191-8971
Whitney HeavnerMolecular Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-6709-4062
National Institutes of Health · USUniversity of California, Berkeley · USJanssen (Belgium) · BEUniversity of Padua · ITUniversity of Southern California · US

Funding

Elucidating the molecular mechanisms of sensory regenerationZIANS009423 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NGAI, JOHN · 2020 to 2025
$7.5M
Supplement for Programs of Gene Expression in Olfactory NeurogenesisR01DC007235 · NIDCD · UNIVERSITY OF CALIFORNIA BERKELEY · PI DUDOIT, SANDRINE · 2005 to 2022
$6.6M
Intramural NIH HHS ZIA NS009423NIDCD NIH HHS R01 DC007235
6 · The paper itself

Abstract

The olfactory epithelium is one of the few regions of the nervous system that sustains neurogenesis throughout life. Its experimental accessibility makes it especially tractable for studying molecular mechanisms that drive neural regeneration in response to injury. In this study, we used single-cell sequencing to identify the transcriptional cascades and epigenetic processes involved in determining olfactory epithelial stem cell fate during injury-induced regeneration. By combining gene expression and accessible chromatin profiles of individual lineage-traced olfactory stem cells, we identified transcriptional heterogeneity among activated stem cells at a stage when cell fates are being specified. We further identified a subset of resting cells that appears poised for activation, characterized by accessible chromatin around wound response and lineage-specific genes prior to their later expression in response to injury. Together these results provide evidence for a latent activated stem cell state, in which a subset of quiescent olfactory epithelial stem cells are epigenetically primed to support injury-induced regeneration.

Identifiers

PMID37961539
PMCPMC10634988
OpenAlexW4388139330

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.