Evidence map›Paper›PMID 37961682›Full record

ArticlebioRxiv : the preprint server for biology2023

Systems profiling reveals recurrently dysregulated cytokine signaling responses in ER+ breast cancer patients' blood.

Brian Orcutt-Jahns, Joao Rodrigues Lima Junior, Russell C Rockne, Adina Matache, Sergio Branciamore, Ethan Hung, Andrei S Rodin, Peter P Lee, Aaron S Meyer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Brian Orcutt-JahnsDepartment of Bioengineering, University of California, Los Angeles (UCLA), USA.ORCID 0000-0002-1436-1224
Joao Rodrigues Lima JuniorDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Russell C RockneDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.ORCID 0000-0002-1557-159X
Adina MatacheDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Sergio BranciamoreDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Ethan HungDepartment of Bioengineering, University of California, Los Angeles (UCLA), USA.
Andrei S RodinDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Peter P LeeDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Aaron S MeyerDepartment of Bioengineering, University of California, Los Angeles (UCLA), USA.ORCID 0000-0003-4513-1840
City of Hope · USUniversity of California, Los Angeles · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Systems Epigenomics of Persistent Bloodstream InfectionU19AI172713 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ELAINE F REED · 2023 to 2026
$11.6M
Experimental-Computational Synthesis of Altered Immune Signaling in Breast CancerU01CA232216 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI LEE, PETER POON-HANG, ROCKNE, RUSSELL CHRISTIAN · 2019 to 2023
$3.0M
NCI NIH HHS P30 CA033572NCI NIH HHS U01 CA232216NIAID NIH HHS U19 AI172713
6 · The paper itself

Abstract

Cytokines mediate cell-to-cell communication across the immune system and therefore are critical to immunosurveillance in cancer and other diseases. Several cytokines show dysregulated abundance or signaling responses in breast cancer, associated with the disease and differences in survival and progression. Cytokines operate in a coordinated manner to affect immune surveillance and regulate one another, necessitating a systems approach for a complete picture of this dysregulation. Here, we profiled cytokine signaling responses of peripheral immune cells from breast cancer patients as compared to healthy controls in a multidimensional manner across ligands, cell populations, and responsive pathways. We find alterations in cytokine responsiveness across pathways and cell types that are best defined by integrated signatures across dimensions. Alterations in the abundance of a cytokine's cognate receptor do not explain differences in responsiveness. Rather, alterations in baseline signaling and receptor abundance suggesting immune cell reprogramming are associated with altered responses. These integrated features suggest a global reprogramming of immune cell communication in breast cancer.

Indexed as

autoimmunitybreast cancerCytokinesimmunologytensor factorization

Identifiers

PMID37961682
PMCPMC10635026
OpenAlexW4388282726

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.