Evidence map›Paper›PMID 37961718›Full record

ArticlebioRxiv : the preprint server for biology2023

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.

Anthony L Hessel, Michel Kuehn, Seong-Won Han, Weikang Ma, Thomas C Irving, Brent A Momb, Taejeong Song, Sakthivel Sadayappan, Wolfgang A Linke, Bradley M Palmer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Anthony L HesselInstitute of Physiology II, University of Muenster; Muenster, Germany.ORCID 0000-0003-4278-4221
Michel KuehnInstitute of Physiology II, University of Muenster; Muenster, Germany.
Seong-Won HanInstitute of Physiology II, University of Muenster; Muenster, Germany.ORCID 0000-0003-1711-658X
Weikang MaBioCAT, Department of Biology, Illinois Institute of Technology; Chicago, USA.ORCID 0000-0001-9535-7114
Thomas C IrvingBioCAT, Department of Biology, Illinois Institute of Technology; Chicago, USA.ORCID 0000-0003-4848-3323
Brent A MombDepartment of Kinesiology, University of Massachusetts - Amherst; Amherst, MA, USA.ORCID 0000-0002-9171-0272
Taejeong SongCenter for Cardiovascular Research, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.ORCID 0000-0001-6648-1263
Sakthivel SadayappanCenter for Cardiovascular Research, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.ORCID 0000-0003-2006-7678
Wolfgang A LinkeInstitute of Physiology II, University of Muenster; Muenster, Germany.ORCID 0000-0003-0801-3773
Bradley M PalmerDepartment of Molecular Physiology and Biophysics, University of Vermont; Burlington, VT, USA.ORCID 0000-0002-4388-3160
Augenstern · DEIllinois Institute of Technology · USUniversity of Cincinnati · USAmherst College · USUniversity of Vermont · US

Funding

The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5M
Time resolved SAXS studies on the RP2/Arl3 complex pp.484-485P41GM103622 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2012 to 2020
$11.9M
Fast myosin binding protein-C and cardiac contractility in heart failureR01HL105826 · NHLBI · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2011 to 2025
$4.5M
Skeletal muscle sarcomere function in health and diseaseR01AR079477 · NIAMS · UNIVERSITY OF MINNESOTA · PI JOSEPH Mark METZGER · 2022 to 2026
$2.6M
Skeletal Myosin-Binding Protein C Regulation and Structural DynamicsR01AR079435 · NIAMS · UNIVERSITY OF ARIZONA · PI Brett A Colson · 2022 to 2026
$2.4M
Slow myosin binding protein-C in skeletal muscle physiologyR01AR078001 · NIAMS · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2020 to 2023
$1.8M
IGF-2R is a new therapeutic target for cardiac ischemia-reperfusion injuryR01HL143490 · NHLBI · UNIVERSITY OF CINCINNATI · PI WANG, YIGANG · 2019 to 2022
$1.6M
Molecular mechanism of hypertrophic cardiomyopathy in populations of South Asian descendantsR01HL130356 · NHLBI · UNIVERSITY OF CINCINNATI · PI SADAYAPPAN, SAKTHIVEL · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL105826NHLBI NIH HHS R01 HL130356NHLBI NIH HHS R01 HL143490NIAMS NIH HHS R01 AR078001NIAMS NIH HHS R01 AR079435NIAMS NIH HHS R01 AR079477NIGMS NIH HHS P30 GM138395NIGMS NIH HHS P41 GM103622
6 · The paper itself

Abstract

In striated muscle, some sarcomere proteins regulate crossbridge cycling by varying the propensity of myosin heads to interact with actin. Myosin-binding protein C (MyBP-C) is bound to the myosin thick filament and is predicted to interact and stabilize myosin heads in a docked position against the thick filament and limit crossbridge formation, the so-called OFF state. Via an unknown mechanism, MyBP-C is thought to release heads into the so-called ON state, where they are more likely to form crossbridges. To study this proposed mechanism, we used the C2

Indexed as

mouseMYBPC2ultrastructureX-ray diffraction

Identifiers

PMID37961718
PMCPMC10634671
OpenAlexW4387866959

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.