Evidence map›Paper›PMID 37962616›Full record

SynthesisEuropean journal of nuclear medicine and molecular imaging2024

The evidence-based role of catecholaminergic PET tracers in Neuroblastoma. A systematic review and a head-to-head comparison with mIBG scintigraphy.

Arnoldo Piccardo, Giorgio Treglia, Francesco Fiz, Zvi Bar-Sever, Gianluca Bottoni, Lorenzo Biassoni, Lise Borgwardt, Bart de Keizer, Nina Jehanno, Egesta Lopci and 10 more

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Head-to-head comparison of [Pediatric radiology · 2026
    Review
  2. Article
  3. Article
  4. Abdominal radiology (New York) · 2025
    Article
  5. Review
  6. [EJNMMI reports · 2025
    Article
  7. Theranostics for Neuroblastoma: Making Molecular Radiotherapy Work Better.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  8. [Frontiers in oncology · 2025
    Article
  9. Performing [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 12 countries.

Arnoldo PiccardoDepartment of Nuclear Medicine, E.O. "Ospedali Galliera", Mura Delle Cappuccine 14, 16128, Genoa, Italy. arnoldo.piccardo@galliera.it.ORCID 0000-0002-6779-1471
Giorgio TregliaClinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Francesco FizDepartment of Nuclear Medicine, E.O. "Ospedali Galliera", Mura Delle Cappuccine 14, 16128, Genoa, Italy.
Zvi Bar-SeverDepartment of Nuclear Medicine, Schneider Children's Medical Center, Tel Aviv University, Tel Aviv, Israel.
Gianluca BottoniDepartment of Nuclear Medicine, E.O. "Ospedali Galliera", Mura Delle Cappuccine 14, 16128, Genoa, Italy.
Lorenzo BiassoniGreat Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Lise BorgwardtRigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Bart de KeizerDepartment of Nuclear Medicine and Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Nina JehannoDepartment of Nuclear Medicine, Institut Curie Paris, Paris, France.
Egesta LopciNuclear Medicine Unit, IRCCS-Humanitas Research Hospital, Rozzano, Milano, Italy.
Lars KurchDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Michela MassolloDepartment of Nuclear Medicine, E.O. "Ospedali Galliera", Mura Delle Cappuccine 14, 16128, Genoa, Italy.
Helen NadelDepartment of Pediatric Nuclear Medicine, Lucile Packard Children's Hospital of Stanford (CA), Palo Alto, USA.
Isabel Roca BielsaUniversitat Autònoma de Barcelona, Barcelona, Spain.
Barry ShulkinSt Jude Children's Research Hospital, Memphis, TN, USA.
Reza ValiDivision of Nuclear Medicine, Department of Diagnostic Imaging, The Hospital for Sick Children of Toronto, Toronto, Canada.
Diego De PalmaNuclear Medicine Unit, Ospedale Di Circolo of Varese, Varese, Italy.
Diego CecchinNuclear Medicine Unit, Department of Medicine - DIMED, University Hospital of Padova, Padua, Italy.
Ana Isabel SantosDepartment of Nuclear Medicine, Hospital Garcia de Orta, Almada, Portugal.
Pietro ZucchettaNuclear Medicine Unit, Department of Medicine - DIMED, University Hospital of Padova, Padua, Italy.
Ente Ospedaliero Ospedali Galliera · ITUniversity of Padua · ITEnte Ospedaliero Cantonale · CHGreat Ormond Street Hospital for Children NHS Foundation Trust · GBHospital for Sick Children · CAHospital Garcia de Orta · PTInstitut Curie · FRIRCCS Humanitas Research Hospital · ITLucile Packard Children's Hospital · USSt. Jude Children's Research Hospital · USTel Aviv University · ILUniversitat Autònoma de Barcelona · ESUniversity Hospital Leipzig · DEUniversity Medical Center Utrecht · NLUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMolecular imaging is pivotal in staging and response assessment of children with neuroblastoma (NB). [

methodsWe searched the PubMed database for studies performing a head-to-head comparison between [

resultsTen studies were selected: two regarding [

conclusionsPET/CT using catecholaminergic tracers shows superior diagnostic performance than mIBG scintigraphy. However, it is still unknown if such superiority can influence clinical decision-making. Nonetheless, the PET examination appears promising for clinical practice as it offers faster image acquisition, less need for sedation, and a single-day examination.

Indexed as

NeuroblastomaRadiopharmaceuticals3-IodobenzylguanidineChildDihydroxyphenylalanineHumansPositron-Emission TomographyPositron Emission Tomography Computed Tomography3-IodobenzylguanidineDihydroxyphenylalaninefluorodopa F 18Radiopharmaceuticals[124I]MIBG, 18F-MFBG, 11C-HED[18F]F-DOPACatecholamineGuidelineNeuroblastomaPaediatric PETPET-CT

Identifiers

PMID37962616
PMCPMC10796700
OpenAlexW4388670002

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.