Evidence map›Paper›PMID 37965313›Full record

ArticleFrontiers in immunology2023

Molecular profiling of clinical remission in psoriatic arthritis reveals dysregulation of

Maria Maddalena Angioni, Alberto Floris, Ignazio Cangemi, Mattia Congia, Elisabetta Chessa, Micaela Rita Naitza, Matteo Piga, Alberto Cauli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maria Maddalena AngioniDepartment of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
Alberto FlorisDepartment of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
Ignazio CangemiDepartment of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
Mattia CongiaDepartment of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
Elisabetta ChessaDepartment of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
Micaela Rita NaitzaDepartment of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
Matteo PigaDepartment of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
Alberto CauliDepartment of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
Azienda Ospedaliero-Universitaria Cagliari · ITUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In psoriatic arthritis (PsA), the primary goal of treatment is clinical remission. This study aimed to characterize the molecular profile underlying the induced clinical remission in patients with PsA, comparing the remission state and the healthy condition. Methods: Whole blood transcriptomic analysis was performed on groups of 14 PsA patients in TNFi-induced clinical remission (DAPSA ≤ 4), 14 PsA patients with active disease (DAPSA > 14), and 14 healthy controls (HCs). Then, all differentially expressed genes (DEGs) derived from remission vs. HC comparison were analyzed for functional and biological characteristics by bioinformatics software. The gene expression of 12 genes was then validated by RT-qPCR in an extended cohort of 39 patients in clinical remission, 40 with active disease, and 40 HCs. Results: The transcriptomic analysis of PsA remission vs. HCs highlighted the presence of 125 DEGs, and out of these genes, 24 were coding genes and showed a great involvement in immune system processes and a functional network with significant interactions. The RT-qPCR validation confirming the down- and upregulation of Conclusion: The transcriptomic profile of clinical remission in PsA is similar to a healthy condition, but not identical, differing for the expression of

Indexed as

Arthritis, PsoriaticGene ExpressionHumansIntracellular Signaling Peptides and ProteinsProto-Oncogene Proteins c-fosRemission InductionSeverity of Illness IndexTreatment OutcomeCCDC50 protein, humanFOS protein, humanIntracellular Signaling Peptides and ProteinsProto-Oncogene Proteins c-fosCCDC50clinical remissionFOSpsoriatic arthritistranscriptomic

Identifiers

PMID37965313
PMCPMC10641465
OpenAlexW4388192562

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.