SynthesisFrontiers in oncology2023
Sarcopenia as a prognostic indicator in colorectal cancer: an updated meta-analysis.
Synthesis in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Prevalence and survival implications of CT-defined low skeletal muscle mass in lung cancer: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis.Frontiers in immunology · 2024Pooled it
- Lower Preoperative Skeletal Muscle Index in Patients with Pathological T4 Colorectal Cancer: An Exploratory Retrospective Cohort Study.Medical sciences (Basel, Switzerland) · 2026Observational
- Sarcopenia in Patients With Cancer and Its Association With Chemotherapy-Induced Peripheral Neurotoxicity.Neurology · 2026Observational
- The clinical application value of body composition in predicting the prognosis of rectal cancer.International journal of clinical oncology · 2026Article
- Skeletal muscle index and hand grip strength as predictors of postoperative recovery in patients with gastrointestinal tumors.BMC gastroenterology · 2026Observational
- Article
- Review
- Sarcopenia is a bad harbinger of cancer-related survival in rectal cancer.Annals of medicine · 2025Article
- Physical fitness and body composition assessments in advanced cancer patients undergoing exenterative surgery - A pilot cohort study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Exercise as Adjuvant Therapy in Colon Cancer: Implications From the CHALLENGE Trial.ANZ journal of surgery · 2025Article
- Preoperative CT-derived sarcopenia as a predictor of postoperative complications in patients undergoing laparoscopic radical resection for non-metastatic colorectal cancer: a retrospective study.International journal of colorectal disease · 2025Article
- Preoperative body composition metrics as predictors for outcomes in colorectal cancer surgeries.Annals of medicine and surgery (2012) · 2025Article
- Preoperative sarcopenia and postoperative accelerated muscle loss negatively impact survival after resection of locally advanced gastric cancer.BMC cancer · 2025Article
- Osteosarcopenia: the coexistence of sarcopenia and osteopenia is predictive of prognosis and postoperative complications after curative resection for colorectal cancer.Surgery today · 2025Article
- Predicting 3-year all-cause mortality in rectal cancer patients based on body composition and machine learning.Frontiers in nutrition · 2025Article
- Mechanisms, assessment, and exercise interventions for skeletal muscle dysfunction post-chemotherapy in breast cancer: from inflammation factors to clinical practice.Frontiers in oncology · 2025Review
- Factors influencing changes in body composition and nutritional status in patients with hyperacute stroke: prospective study.Frontiers in nutrition · 2025Article
- Prognostic Value of Sarcopenia in Elderly Patients with Metastatic Non-Small-Cell Lung Cancer Undergoing Radiotherapy.Current oncology (Toronto, Ont.) · 2024Article
- Thigh muscle by CT images as a predictor of mortality in patients with newly diagnosed colorectal cancer.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sarcopenia, often observed in the elderly, is associated with declining skeletal muscle mass and impaired muscle function. This condition has been consistently linked to a less favorable prognosis in various malignancies. Computed tomography (CT) is a frequently employed modality for evaluating skeletal muscle mass, enabling the measurement of the skeletal muscle index (SMI) at the third lumbar vertebra (L3) level. This measurement serves as a defining criterion for sarcopenia. The meta-analysis dealt with evaluating the promise sarcopenia held as a prognostic indicator in individuals with colorectal cancer. Methods: Research relevant to the subject was determined by systematically searching PubMed, Embase, Web of Science, WANFANG, and CNKI (up to June 11, 2023, published studies). In this meta-analysis, the incidence of sarcopenia in individuals with colorectal cancer was combined to analyze the disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) of these individuals with and without sarcopenia. The included research was evaluated for quality per the Newcastle-Ottawa Scale (NOS) score. In the multivariate analysis of each study, the direct extraction of hazard ratio (HR) with a 95% confidence interval (CI) was executed. STATA 11.0 was applied to integrate and statistically analyze the data. Results: Overall 20 articles participated in this meta-analysis. A 34% incidence of sarcopenia was noted in colorectal cancer. The presence of sarcopenia denoted a decrease in OS (HR=1.72,95% CI=1.45-2.03), DFS (HR=1.42,95% CI=1.26-1.60) and CSS (HR=1.48,95% CI=1.26-1.75) in individuals with colorectal cancer. In addition, the subgroup analysis depicted a pattern consistent with the overall analysis results. Conclusion: CT-defined sarcopenia exhibits promise as an indicator of survival prognosis in individuals with colorectal cancer. Future studies need a more rigorous definition of sarcopenia to further verify these findings. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023431435.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.