Evidence map›Paper›PMID 37966252›Full record

ArticlemSystems2023

Interactome between ASFV and host immune pathway proteins.

Qijun Wu, Yingying Lei, Ya Zuo, Ji Zhang, Fenglin Guo, Weize Xu, Tanghui Xie, Dang Wang, Guiqing Peng, Xiangru Wang and 4 more

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
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  9. Review
  10. Review
  11. Article
  12. Review
  13. When ASFV Infection Meets the cGAS-STING Signaling Pathway.Transboundary and emerging diseases · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Qijun Wu *State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.ORCID 0009-0001-9268-9161
Yingying Lei *State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0002-0424-4032
Ya Zuo *College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Ji ZhangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Fenglin GuoState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Weize XuState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Tanghui XieHubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China.
Dang WangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0003-3394-3702
Guiqing PengState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0001-8813-6663
Xiangru WangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0003-0191-1378
Huanchun ChenState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Zhenfang FuState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Gang CaoState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0001-7060-5185
Jinxia DaiState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0001-7060-5185
Huazhong Agricultural University · CNUniversity of Georgia · US

Funding

Department of Finance of Guangdong Province () 2019B020211003MOST | National Key Research and Development Program of China (NKPs) 2021YFD1800100MOST | National Natural Science Foundation of China (NSFC) 31941005, 31941014
6 · The paper itself

Abstract

importanceAfrican swine fever (ASF), caused by African swine fever virus (ASFV), has become a major crisis for the pork industry in recent years. The mechanism for ASFV pathology and the clinical symptoms difference of ASF between domestic pigs and reservoir hosts remain to be elucidated. We deciphered the comprehensive protein-protein interaction (PPI) network between ASFV and host immune pathways. The intensive PPI network contained both ASFV-host immune pathway PPI and ASFV-ASFV PPI information, providing a comprehensive ASFV-host interaction landscape. Furthermore, the ASFV-host PPI difference between domestic pigs and warthogs was explored, which will be instructive for exploring essential candidates involved in ASFV pathology. Moreover, we screened the inhibitory effect of ASFV proteins in the PPI with cGAS-STING pathway on IFN-I and NF-κB, further providing possible functions of ASFV-host PPI network in innate immune regulation.

Indexed as

African Swine FeverAfrican Swine Fever VirusInterferon Type IAnimalsNF-kappa BSus scrofaSwineInterferon Type INF-kappa BAfrican swine fever virushigh-throughput yeast two-hybrid screeninghost immune pathwayprotein-protein interaction

Identifiers

PMID37966252
PMCPMC10734461
OpenAlexW4388698138

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.