Evidence map›Paper›PMID 37969083›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Thromboxane-induced cerebral microvascular rarefaction predicts depressive symptom emergence in metabolic disease.

Brayden D Halvorson, Yuki Bao, Krishna K Singh, Stephanie J Frisbee, Vladimir Hachinski, Shawn N Whitehead, C W James Melling, Paul D Chantler, Daniel Goldman, Jefferson C Frisbee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Brayden D HalvorsonDepartment of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.
Yuki BaoDepartment of Biomedical Engineering, University of Western Ontario, London, Ontario, Canada.
Krishna K SinghDepartment of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-6097-8401
Stephanie J FrisbeeDepartment of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada.
Vladimir HachinskiDepartment of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.
Shawn N WhiteheadDepartment of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0003-4728-8067
C W James MellingDepartment of Kinesiology, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-7474-1886
Paul D ChantlerDivision of Exercise Physiology, West Virginia University, Morgantown, West Virginia, United States.ORCID 0000-0001-6960-9728
Daniel GoldmanDepartment of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.
Jefferson C FrisbeeDepartment of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0003-2751-0599
Western University · CAWest Virginia University · US

Funding

Skeletal Muscle Microcirculation in Obese Zucker RatsR01DK064668 · NIDDK · WEST VIRGINIA UNIVERSITY · PI FRISBEE, JEFFERSON C · 2004 to 2009
$1.1M
American Heart Association (AHA) 0330194NAmerican Heart Association (AHA) 0740129NAmerican Heart Association (AHA) IRG14330015Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2018-05450Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2019-06086HHS | National Institutes of Health (NIH) DK64668HHS | National Institutes of Health (NIH) RR2865ARNIDDK NIH HHS R01 DK064668
6 · The paper itself

Abstract

Previous studies have suggested that the loss of microvessel density in the peripheral circulation with evolving metabolic disease severity represents a significant contributor to impaired skeletal muscle oxygenation and fatigue-resistance. Based on this and our recent work, we hypothesized that cerebral microvascular rarefaction was initiated from the increased prooxidant and proinflammatory environment with metabolic disease and is predictive of the severity of the emergence of depressive symptoms in obese Zucker rats (OZRs). In male OZR, cerebrovascular rarefaction followed the emergence of elevated oxidant and inflammatory environments characterized by increased vascular production of thromboxane A

Indexed as

Metabolic DiseasesMetabolic SyndromeMicrovascular RarefactionAnimalsDepressionMaleObesityOxidantsRatsRats, ZuckerThromboxanesOxidantsThromboxanescerebral vasculopathycognitive impairmentsmicrovascular dysfunctionobesity and insulin resistancerodent models of metabolic disease

Identifiers

PMID37969083
PMCPMC11551004
OpenAlexW4388727703

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.