ReviewCJC pediatric and congenital heart disease2023
Exercise Pathophysiology and Testing in Individuals With a Fontan Circulation.
Review in CJC pediatric and congenital heart disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Cardiopulmonary Exercise Test Interpretation Across the Lifespan in Congenital Heart Disease: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2025Guideline
- Beyond Body Mass Index: Skeletal Muscle Mass as a Marker of Physiologic Reserve in Fontan Circulation.Pediatric cardiology · 2026Article
- NT-proBNP and other blood biomarkers in patients after Fontan Surgery: Prognostic, diagnostic, and management implications.International journal of cardiology. Congenital heart disease · 2026Article
- Risk Factors of Exercise Intolerance in Children and Adolescents After Total Cavopulmonary Connection.Journal of cardiovascular development and disease · 2026Article
- Utility of Single Ventricle Longitudinal Strain and Evaluation of its Clinical Implications in Patients with Fontan Circulation.Pediatric cardiology · 2026Article
- Augmenting Venous Return in Fontan Circulation: The Role of the Skeletal Muscle Pump and Implications for Mechanical Compression Devices-A Review of the Literature.Pediatric cardiology · 2026Review
- High BMI Associated with Lower Child Opportunity Index Negatively Impacts Exercise Capacity in Fontan Patients.Pediatric cardiology · 2026Article
- Exercise hemodynamics in adults with Fontan circulation assessed by noninvasive impedance cardiography.Frontiers in cardiovascular medicine · 2026Article
- Cardiopulmonary Test in Fontan Patients: Is the Type of Ergometer Critical?Journal of cardiovascular development and disease · 2025Article
- Determinants of cardiac output in health and heart failure.Experimental physiology · 2025Review
- Serial Exercise Testing in Children With Known or Suspected Congenital and Acquired Heart Disease: A Narrative Review and Survey of Current Practice.Journal of the American Heart Association · 2025Review
- Skeletal Muscle Oxygen Dynamics during Rehabilitation of Children with Congenital Heart Disease: A Comparative Study of Two Cases.Physical therapy research · 2025Article
- Exercise Performance: A Fontan Phenotype Predictive of Long-Term Survival.JACC. Advances · 2024Article
- Impact of 4D-Flow CMR Parameters on Functional Evaluation of Fontan Circulation.Pediatric cardiology · 2024Article
- Home-based long-term physical endurance and inspiratory muscle training in children and adults with Fontan circulation.Frontiers in cardiovascular medicine · 2024Article
- Reference Values of Cardiopulmonary Exercise Test Parameters in the Contemporary Paediatric Population.Sports medicine - open · 2023Article
- Unifying nomenclature describing the individuals with Fontan circulation.Annals of pediatric cardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Fontan circulation, a surgical palliation for single-ventricle congenital heart disease, profoundly impacts the cardiopulmonary response to exercise. Reliant on passive pulmonary blood flow, the Fontan circulation has limited capacity to augment cardiac output as necessary to supply working muscles during exercise. Cardiopulmonary exercise testing (CPET) objectively assesses cardiorespiratory fitness and provides insight into the etiology of exercise intolerance. Furthermore, CPET variables, such as peak oxygen consumption and submaximal variables, have prognostic value and may be used as meaningful endpoints in research studies. CPET is also useful in clinical research applications to assess the effect of pharmacologic or other interventions. Medical therapies to improve exercise tolerance in individuals with a Fontan circulation, such as pulmonary vasodilators, may modestly improve peak oxygen consumption. Exercise training focused on aerobic fitness and lower extremity strength may have a more consistent and larger impact on these measures of aerobic fitness. CPET is a valuable diagnostic and prognostic tool for those with a Fontan circulation. Newer ancillary assessments, such as noninvasive peripheral venous pressure monitoring and cardiac output measurements, hold promise to provide a more nuanced insight into the underlying pathophysiology.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.