Evidence map›Paper›PMID 37969928›Full record

ArticleCJC pediatric and congenital heart disease2022

Association of Acute Anti-inflammatory Treatment With Medium-term Outcomes for Coronary Artery Aneurysms in Kawasaki Disease.

Kevin G Friedman, Brian W McCrindle, Kyle Runeckles, Nagib Dahdah, Ashraf S Harahsheh, Michael Khoury, Sean Lang, Cedric Manlhiot, Adriana H Tremoulet, Geetha Raghuveer and 9 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CJC pediatric and congenital heart disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 2 countries.

Kevin G FriedmanBoston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Brian W McCrindleDivision of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Kyle RunecklesDivision of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Nagib DahdahDivision of Pediatric Cardiology, Centre Hospitalier Universitaire Ste-Justine, University of Montreal, Montreal, Québec, Canada.
Ashraf S HarahshehDivision of Cardiology, Department of Pediatrics, Children's National Hospital, the George Washington University School of Medicine & Health Sciences, Washington, District of Columbia, USA.
Michael KhouryDepartment of Pediatrics, Stollery Children's Hospital, Edmonton, Alberta, Canada.
Sean LangHeart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Cedric ManlhiotDivision of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Adriana H TremouletDepartment of Pediatrics, Rady Children's Hospital-San Diego, University of California San Diego, San Diego, California, USA.
Geetha RaghuveerDepartment of Pediatrics, Children's Mercy Hospital, Kansas City, Missouri, USA.
Elif Seda Selamet TierneyDepartment of Pediatrics, Division of Pediatric Cardiology, School of Medicine, Stanford University, Palo Alto, California, USA.
Pei-Ni JonePediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
Jennifer S LiDivision of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.
Jacqueline R SzmuszkoviczDepartment of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA.
Kambiz NoroziDivision of Cardiology, Department of Pediatrics, University of Western Ontario, London, Ontario, Canada.
Supriya S JainMaria Fareri Children's Hospital at Westchester Medical Center Health, New York Medical College, Valhalla, New York, USA.
Angela T YetmanDepartment of Pediatrics, Children's Hospital & Medical Center of Omaha, Omaha, Nebraska, USA.
Jane W NewburgerBoston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
International Kawasaki Disease Registry
Boston Children's Hospital · USStollery Children's Hospital · CAUniversity of Toronto · CAWestern University · CACentre Hospitalier Universitaire Sainte-Justine · CAChildren's Hospital Colorado · USChildren's Hospital of Los Angeles · USChildren's Mercy Hospital · USCincinnati Children's Hospital Medical Center · USDuke Medical Center · USGeorge Washington University Hospital · USMaria Fareri Children's Hospital · USRady Children's Hospital-San Diego · USStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The impact of adjunctive anti-inflammatory treatment on outcomes for patients with Kawasaki disease (KD) and coronary artery aneurysms (CAAs) is unknown. Methods: Using data from the International KD Registry in patients with ≥ medium CAA we evaluate associations of treatment with outcomes and major adverse cardiac events (MACE). Results: Medium or large CAA was present in 527 (32%) patients. All were treated with intravenous immunoglobulin (IVIG), 70% were male, and the median age was 1.3 years (interquartile range: 0.4-4.0 years). The most common acute therapies included single IVIG alone in 243 (46%), multiple IVIG in 100 (19%), multiple IVIG + corticosteroids in 75 (14%), and multiple IVIG + infliximab + corticosteroids in 44 (8%) patients. Patients who received therapy beyond single IVIG had a larger CA Conclusions: Persistence of CAA and MACE are more strongly associated with baseline severity CAA than with acute adjuvant anti-inflammatory therapy. Patients who received late adjunctive therapy are at higher risk for worse outcomes.

Identifiers

PMID37969928
PMCPMC10642124
OpenAlexW4283011358

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.