Evidence map›Paper›PMID 37974334›Full record

ArticleVirulence2024

Protective efficacy of a novel recombinant influenza virus carrying partial human metapneumovirus F protein epitopes.

Fang Sun, Guanglin Lei, Chongyu Tian, Zhifang Bai, Changqing Bai, Yufeng Li, Zhuoya Deng, Hao Yang, Cong Li, Zhongpeng Zhao and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Fang SunThe Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Guanglin LeiThe Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Chongyu TianThe Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Zhifang BaiThe Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Changqing BaiThe Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Yufeng LiThe Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Zhuoya DengThe Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Hao YangThe Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Cong LiThe Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Zhongpeng ZhaoState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Yan NiuCollege of Basic Medical Science, Inner Mongolia Medical University, Hohhot, China.
Penghui YangThe Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Chinese PLA General Hospital · CNAcademy of Military Medical Sciences · CNMongolian National University of Medical Sciences · MN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human metapneumovirus (HMPV) is a leading cause of acute respiratory tract infections in infants and children. Currently, no approved HMPV vaccine is available. We developed a novel recombinant influenza virus, which carried partial HMPV F protein (HMPV-F) epitopes, utilizing reverse genetics. The novel single-stranded RNA virus, termed rFLU-HMPV/F-NA, was synthesized in the neuraminidase (NA) fragment of influenza virus A/PuertoRico/8/34 (PR8). The morphological characteristics of rFLU-HMPV/F-NA were consistent with the wild-type flu virus. The virus could passage in specific pathogen-free (SPF) chicken embryos for at least five consecutive generations with haemagglutinin (HA) titres of 2

Indexed as

EpitopesInfluenza A virusMetapneumovirusParamyxoviridae InfectionsViral Fusion ProteinsViral VaccinesAnimalsAntibodies, ViralChick EmbryoFemaleHumansMiceMice, Inbred BALB CReverse GeneticsVaccines, SyntheticAntibodies, ViralEpitopesVaccines, SyntheticViral Fusion ProteinsViral VaccinesHMPVHMPV vaccineInfluenza virusreverse genetics

Identifiers

PMID37974334
PMCPMC12506902
OpenAlexW4388773033

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.