Evidence map›Paper›PMID 37974566›Full record

ArticleNature. Mental health2023

Recent advances in the neuroscience of spontaneous and off-task thought: implications for mental health.

Aaron Kucyi, Julia W Y Kam, Jessica R Andrews-Hanna, Kalina Christoff, Susan Whitfield-Gabrieli

Abstract read
In one paragraph

Article in Nature. Mental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Real-time fMRI-triggered experience-sampling: a proof-of-concept study.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Uncovering the embodied dimension of the wandering mind.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Disorganisation and depression: a re-examination of how we think and speak when depressed.European archives of psychiatry and clinical neuroscience · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aaron KucyiDepartment of Psychological and Brain Sciences, Drexel University.ORCID 0000-0001-6707-0028
Julia W Y KamDepartment of Psychology and Hotchkiss Brain Institute, University of Calgary.
Jessica R Andrews-HannaDepartment of Psychology, Cognitive Science, University of Arizona.
Kalina ChristoffDepartment of Psychology, University of British Columbia.
Susan Whitfield-GabrieliDepartment of Psychology, Northeastern University.

Funding

Connected Lives - Overcoming the Self through Empathy (CLOSE): A Dyadic, Multi-Method StudyR01MH125414 · NIMH · UNIVERSITY OF ARIZONA · PI Jessica Renee Andrews-Hanna, DAVID A SBARRA · 2021 to 2026
$3.0M
Real-time fMRI for insular cortex brain state-triggered experience samplingR21MH129630 · NIMH · DREXEL UNIVERSITY · PI KUCYI, AARON · 2023 to 2024
$417k
Investigating electroencephalographic predictors of default mode network anticorrelation for personalized neurofeedbackR21MH127384 · NIMH · NORTHEASTERN UNIVERSITY · PI KUCYI, AARON · 2022 to 2023
$415k
NIMH NIH HHS R01 MH125414NIMH NIH HHS R21 MH127384NIMH NIH HHS R21 MH129630
6 · The paper itself

Abstract

People spend a remarkable 30-50% of awake life thinking about something other than what they are currently doing. These experiences of being "off-task" can be described as spontaneous thought when mental dynamics are relatively flexible. Here we review recent neuroscience developments in this area and consider implications for mental wellbeing and illness. We provide updated overviews of the roles of the default mode network and large-scale network dynamics, and we discuss emerging candidate mechanisms involving hippocampal memory (sharp-wave ripples, replay) and neuromodulatory (noradrenergic and serotonergic) systems. We explore how distinct brain states can be associated with or give rise to adaptive and maladaptive forms of thought linked to distinguishable mental health outcomes. We conclude by outlining new directions in the neuroscience of spontaneous and off-task thought that may clarify mechanisms, lead to personalized biomarkers, and facilitate therapy developments toward the goals of better understanding and improving mental health.

Identifiers

PMID37974566
PMCPMC10653280

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.