Evidence map›Paper›PMID 37974929›Full record

ArticleNewborn (Clarksville, Md.)

Clinical Correlates of Cholestasis in Preterm Infants with Surgical Necrotizing Enterocolitis.

Parvesh Mohan Garg, Isabella Pittman, Joe Yi, Victoria G Weis, Ricardo Jorge Rodriguez, Mitchell R Ladd, Jessica L Rauh, Anna Greene McDonald, Cherrie Welch, Muralidhar Hebbur Premkumar and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Newborn (Clarksville, Md.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Parvesh Mohan GargDepartment of Pediatrics/Neonatology, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America.
Isabella PittmanDepartment of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Joe YiFrank Porter Graham Child Development Institute, University of North Carolina at Chapel Hill, NC, United States of America.
Victoria G WeisDepartment of Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America.
Ricardo Jorge RodriguezDepartment of Pediatrics/Neonatology, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America.
Mitchell R LaddDepartment of Pediatric Surgery, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America.
Jessica L RauhDepartment of Pediatric Surgery, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America.
Anna Greene McDonaldDepartment of Pathology, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America.
Cherrie WelchDepartment of Pediatrics/Neonatology, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America.
Muralidhar Hebbur PremkumarTexas Children Hospital, Baylor College of Medicine, Houston, Texas, United States of America.
Padma P GargDepartment of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Akhil MaheshwariGlobal Newborn Society, Clarksville, Maryland, United States of America.
Atrium Health Wake Forest Baptist · USUniversity of Mississippi Medical Center · USWake Forest University · USBaylor College of Medicine · USLouisiana State University Health Sciences Center Shreveport · USUniversity of North Carolina at Chapel Hill · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2016 to 2025
$38.2M
Effect of Platelet Transfusions on Neonatal Intestinal InjuryR01HL133022 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2017 to 2020
$1.6M
Red Cell Transfusion-associated Necrotizing Enterocolitis in Premature InfantsR01HL124078 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL124078NHLBI NIH HHS R01 HL133022NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Background: We sought to investigate the clinical determinants and outcomes of cholestasis in preterm infants with surgical necrotizing enterocolitis (sNEC). Methods: Retrospective comparison of clinical information in preterm infants who developed cholestasis vs those who did not. Results: Sixty-two (62/91, 68.1%) infants with NEC developed cholestasis at any time following the onset of illness. Cholestasis was seen more frequently in those who had received ionotropic support at 24 hours following sNEC diagnosis (87.1% vs 58.6%; Conclusion: Cholestasis was seen in 68% of infants following surgical NEC. The most likely contributive factors are intestinal failure and subsequent PN dependence for longer periods. Our data suggest that identification and prevention of risk factors such as sepsis and surgical complications and early feeds following NEC surgery may improve outcomes.

Indexed as

AdhesionsAnthropometricBell’s criteriaCholestasisFarnesoid XFenton growthFish oil-containing lipid emulsionFistulaIleocecal valveInfantIntestinal failureIntralipidsLiver X receptorsLogistic regressionNecrotizing enterocolitisNeonateOutcomeParenteral nutritionPerforationsPneumatosisPneumoperitoneumPortal venous gasPrematurePretermSoybean oil–medium chain triglycerides–olive oil–fish oilStrictureSurgical site infectionTerm-equivalent ageWeight-for-lengthWound dehiscencez-scores

Identifiers

PMID37974929
PMCPMC10653206
OpenAlexW4387104394

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.