Evidence map›Paper›PMID 37975142›Full record

ArticleJournal of diabetes and metabolic disorders2023

VDR downregulation and promoter hypermethylation as one of the causes for triggering type 2 diabetes mellitus: Clinical and molecular studies.

Najeebul Tarfeen, Shariq Rashid Masoodi, Khair Ul Nisa, Shafat Ali, Mir Bilal Ahmad, Bashir Ahmad Ganai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes and metabolic disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Najeebul TarfeenCentre of Research for Development, University of Kashmir, Srinagar, 190006 Jammu and Kashmir India.ORCID 0000-0003-1916-3240
Shariq Rashid MasoodiDivision of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir India.
Khair Ul NisaDepartment of Environmental Science, University of Kashmir, Srinagar, 190006 Jammu and Kashmir India.
Shafat AliCentre of Research for Development, University of Kashmir, Srinagar, 190006 Jammu and Kashmir India.
Mir Bilal AhmadDepartment of Biochemistry, University of Kashmir, Srinagar, 190006 Jammu and Kashmir India.
Bashir Ahmad GanaiCentre of Research for Development, University of Kashmir, Srinagar, 190006 Jammu and Kashmir India.
University of Kashmir · INSher-i-Kashmir Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Our present study was to investigate the methylation and Gene expression of the vitamin D receptor (VDR) gene in the causing T2DM and to determine the inflammatory biomarkers in exaggerating T2DM in Kashmiri population. Methods: In this study, T2DM cases ( Results: Studies using RT-PCR demonstrated that patients with diabetes had a lower degree of VDR expression than control subjects ( Conclusions: This study suggests the hypermethylation and down expression of VDR as one of the basis for causing T2DM in kashmiri individuals, exaggerated by enhanced degree of TNF-α, CRP, IL-6 and leptin and diminished concentration of IL-10 and adiponectin in T2DM. Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-023-01266-6.

Indexed as

Diabetes mellitusInflammatory biomarkersPromoter methylationVDRVitamin D

Identifiers

PMID37975142
PMCPMC10638154
OpenAlexW4385382094

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.