Evidence map›Paper›PMID 37978334›Full record

ArticleScientific reports2023

Higher HDL cholesterol levels are associated with increased markers of interstitial myocardial fibrosis in the MultiEthnic Study of Atherosclerosis (MESA).

Omar Chehab, Elie Akl, Ashkan Abdollahi, Ralph Zeitoun, Bharath Ambale-Venkatesh, Colin Wu, Russell Tracy, Roger S Blumenthal, Wendy S Post, Joao A C Lima and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Radiolabeling lipoproteins to study and manage disease.European journal of nuclear medicine and molecular imaging · 2025
    Review
  3. Dysfunctional high-density lipoprotein: an updated review.Frontiers in cardiovascular medicine · 2025
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Omar ChehabDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Elie AklDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Ashkan AbdollahiDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Ralph ZeitounDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Bharath Ambale-VenkateshDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Colin WuOffice of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Russell TracyDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA.
Roger S BlumenthalDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Wendy S PostDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Joao A C LimaDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Annabelle RodriguezCenter for Vascular Biology, University of Connecticut Health, Farmington, CT, USA. rodriguezoquendo@uchc.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USNational Institutes of Health · USUConn Health · USUniversity of Vermont · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READINGN01HC095169 · HC · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI DETRANO, ROBERT · 1999 to 2001
$124k
NCATS NIH HHS UL1 TR001079NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC- 95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169
6 · The paper itself

Abstract

Emerging research indicates that high HDL-C levels might not be cardioprotective, potentially worsening cardiovascular disease (CVD) outcomes. Yet, there is no data on HDL-C's association with other CVD risk factors like myocardial fibrosis, a key aspect of cardiac remodeling predicting negative outcomes. We therefore aimed to study the association between HDL-C levels with interstitial myocardial fibrosis (IMF) and myocardial scar measured by CMR T1-mapping and late-gadolinium enhancement (LGE), respectively. There were 1863 participants (mean age of 69 years) who had both serum HDL-C measurements and underwent CMR. Analysis was done among those with available indices of interstitial fibrosis (extracellular volume fraction [ECV]; N = 1172 and native-T1; N = 1863) and replacement fibrosis by LGE (N = 1172). HDL-C was analyzed as both logarithmically-transformed and categorized into < 40 (low),40-59 (normal), and ≥ 60mg/dL (high). Multivariable linear and logistic regression models were constructed to assess the associations of HDL-C with CMR-obtained measures of IMF, ECV% and native-T1 time, and myocardial scar, respectively. In the fully adjusted model, each 1-SD increment of log HDL-C was associated with a 1% increment in ECV% (p = 0.01) and an 18-ms increment in native-T1 (p < 0.001). When stratified by HDL-C categories, those with high HDL-C (≥ 60mg/dL) had significantly higher ECV (β = 0.5%, p = 0.01) and native-T1 (β = 7 ms, p = 0.01) compared with those with normal HDL-C levels. Those with low HDL-C were not associated with IMF. Results remained unchanged after excluding individuals with a history of myocardial infarction. Neither increasing levels of HDL-C nor any HDL-C category was associated with the prevalence of myocardial scar. Increasing levels of HDL-C were associated with increased markers of IMF, with those with high levels of HDL-C being linked to subclinical fibrosis in a community-based setting.

Indexed as

AtherosclerosisCardiomyopathiesAgedCholesterol, HDLCicatrixContrast MediaFibrosisGadoliniumHumansMagnetic Resonance Imaging, CineMyocardiumPredictive Value of TestsCholesterol, HDLContrast MediaGadolinium

Identifiers

PMID37978334
PMCPMC10656454
OpenAlexW4388764595

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.