Evidence map›Paper›PMID 37979913›Full record

ArticleThe Journal of biological chemistry2023

A gastrointestinal locally activating Janus kinase inhibitor to treat ulcerative colitis.

Yingzi Bu, Mohamed Dit Mady Traore, Luchen Zhang, Lu Wang, Zhongwei Liu, Hongxiang Hu, Meilin Wang, Chengyi Li, Duxin Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yingzi BuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA; Michigan Institute for Computational Discovery & Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Mohamed Dit Mady TraoreDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA.
Luchen ZhangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA.
Lu WangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA.
Zhongwei LiuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA.
Hongxiang HuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA.
Meilin WangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA.
Chengyi LiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA.
Duxin SunDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, North Campus Research Complex, Ann Arbor, Michigan, USA. Electronic address: duxins@umich.edu.
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gary D Luker · 1988 to 2026
$178.2M
NCI NIH HHS P30 CA046592
6 · The paper itself

Abstract

In this study, we integrated machine learning (ML), structure-tissue selectivity-activity-relationship (STAR), and wet lab synthesis/testing to design a gastrointestinal (GI) locally activating JAK inhibitor for ulcerative colitis treatment. The JAK inhibitor achieves site-specific efficacy through high local GI tissue selectivity while minimizing the requirement for JAK isoform specificity to reduce systemic toxicity. We used the ML model (CoGT) to classify whether the designed compounds were inhibitors or noninhibitors. Then we used the regression ML model (MTATFP) to predict their IC

Indexed as

Colitis, UlcerativeDrug DesignJanus Kinase InhibitorsHumansJanus Kinase 1Janus Kinase 2Machine LearningProtein IsoformsStructure-Activity RelationshipJanus Kinase 1Janus Kinase 2Janus Kinase InhibitorsProtein IsoformsGI locally activatingJanus kinase (JAK) inhibitorsmachine learning (ML)structure-tissue selectivity-activity-relationship (STAR)ulcerative colitis

Identifiers

PMID37979913
PMCPMC10755797
OpenAlexW4388749684

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.