Evidence map›Paper›PMID 37984559›Full record

ReviewOsteoarthritis and cartilage2024

Multiple joint osteoarthritis (MJOA): What's in a name?

Amanda E Nelson

Open access · bronzeAbstract readReview
In one paragraph

Review in Osteoarthritis and cartilage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Osteoarthritis as a systemic disease.Nature reviews. Rheumatology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Innate Immunity and Synovitis: Key Players in Osteoarthritis Progression.International journal of molecular sciences · 2024
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Amanda E NelsonDepartment of Medicine, Division of Rheumatology, Allergy, and Immunology, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: aenelson@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Amanda E Nelson · 2019 to 2026
$6.1M
NIAMS Multidisciplinary Clinical Research CenterP60AR064166 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARSHALL, STEPHEN WILLIAM · 2013 to 2017
$5.8M
Is the gut important in multiple joint osteoarthritis? A multimodal investigation in humans and pet dogsR01AR080733 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Duncan Lascelles, Amanda E Nelson · 2022 to 2026
$3.8M
Johnston County Osteoarthritis Project: Arthritis, Disability, and Other Chronic DiseasesU01DP006266 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NELSON, AMANDA E · 2016 to 2020
$3.8M
Identifying determinants of rapid structural and/or clinical progression in knee osteoarthritis by quantitative assessment of structural features on radiographsR01AR080742 · NIAMS · UNIVERSITY OF ARIZONA · PI JEFFREY W DURYEA, C KENT KWOH · 2022 to 2026
$3.7M
The Johnston County OA Project: Arthritis and DisabilityU01DP003206 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JORDAN, JOANNE M. · 2011 to 2015
$3.2M
Healthy knee aging vs. osteoarthritis in three large diverse cohorts: What is the clinical relevance of structural changes seen on radiographs?R01AR078187 · NIAMS · UNIVERSITY OF ARIZONA · PI DURYEA, JEFFREY W, KWOH, C KENT · 2021 to 2022
$2.4M
Development of an AI/ML-ready knee ultrasound dataset in a population-based cohortR01AR077060 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NELSON, AMANDA E · 2020 to 2024
$2.0M
Mentoring in Patient Oriented Research in OsteoarthritisK24AR081368 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Amanda E Nelson · 2022 to 2026
$916k
ACL HHS U01DP003206ACL HHS U01DP006266NCCDPHP CDC HHS U01 DP003206NCCDPHP CDC HHS U01 DP006266NIAMS NIH HHS K24 AR081368NIAMS NIH HHS P30 AR072580NIAMS NIH HHS P60 AR064166NIAMS NIH HHS R01 AR077060NIAMS NIH HHS R01 AR078187NIAMS NIH HHS R01 AR080733NIAMS NIH HHS R01 AR080742
6 · The paper itself

Abstract

objectiveTo summarize the current state of the literature regarding multi-joint osteoarthritis (MJOA) and discuss important future directions.

designA narrative review of the author's work and other key references on this topic with a focus on the Johnston County studies, definitions of MJOA and their impact, multi-site pain in osteoarthritis (OA), genetics and biomarkers in MJOA, and perspectives on future work.

resultsMJOA is variably defined and lacks a clear consensus definition, making comprehensive study challenging. Involvement of both symptoms and structural changes of OA in multiple joints in an individual is common, but patterns vary by sex, race/ethnicity, and other factors. Outcomes (e.g., general health, function, falls, mortality) are negatively impacted by a greater whole-body OA burden. Recent genetic and biomarker studies including whole-body OA assessments have begun to shed some light on potentially unique factors in the MJOA population.

conclusionsConsideration of MJOA is essential for ongoing study of OA phenotypes, epidemiology, risk factors, genetics, biomarkers, and outcomes, to fully understand and eventually limit the negative impact of OA burden on health.

Indexed as

OsteoarthritisBiomarkersEthnicityHumansNorth CarolinaPhenotypeBiomarkersBiomarkersEpidemiologyGeneralized osteoarthritisMulti-joint osteoarthritis

Identifiers

PMID37984559
PMCPMC10922529
OpenAlexW4388807394

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.