Evidence map›Paper›PMID 37985659›Full record

ArticleNPJ biofilms and microbiomes2023

Vaginal microbial dynamics and pathogen colonization in a humanized microbiota mouse model.

Marlyd E Mejia, Vicki Mercado-Evans, Jacob J Zulk, Samantha Ottinger, Korinna Ruiz, Mallory B Ballard, Stephanie W Fowler, Robert A Britton, Kathryn A Patras

Open access · goldAbstract read
In one paragraph

Article in NPJ biofilms and microbiomes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Type 2 diabetes mellitus exacerbates vaginal group BbioRxiv : the preprint server for biology · 2026
    Article
  12. Review
  13. Microbiota-dependent IFN-L controls uterine and placental immunity.bioRxiv : the preprint server for biology · 2026
    Article
  14. Inflammatory landscape ofFrontiers in immunology · 2026
    Article
  15. Article
  16. Bacteriophage-mediated reduction of uropathogenicbioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Review
  19. TSST-1 promotes colonization ofInfection and immunity · 2025
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Marlyd E MejiaDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Vicki Mercado-EvansDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Jacob J ZulkDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Samantha OttingerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Korinna RuizDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Mallory B BallardDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Stephanie W FowlerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-0785-4274
Robert A BrittonDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Kathryn A PatrasDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA. katy.patras@bcm.edu.ORCID 0000-0003-2631-8810
Baylor College of Medicine · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Initiative for Maximizing Student Development (IMSD) ProgramR25GM056929 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 1998 to 2023
$12.4M
Organoid Cultivation CoreU19AI157981 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI LEMON, KATHERINE PAIGE · 2021 to 2025
$12.4M
The Clinical Translational Research Certificate of Added Qualification ProgramT32GM136554 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Melissa Suter, IGNATIA B VAN DEN VEYVER · 2020 to 2026
$3.0M
Contribution of immune modulation, metabolism, and microbiota to Group B Streptococcal urinary tract infectionR01DK128053 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI PATRAS, KATY · 2021 to 2025
$2.3M
Baylor College of Medicine Initiative for Maximizing Student DevelopmentT32GM152777 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PANGAS, STEPHANIE A., PEREIRA, FRED A · 2024 to 2024
$547k
Characterizing the Impact of Gestational Diabetes on Immunity and Group B Streptococcal Virulence in the Maternal Reproductive TractF31AI167547 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MERCADO, VICKI · 2022 to 2025
$178k
Characterizing the impact of maternal immune response to urinary tract infection on preterm birthF31HD111236 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI OTTINGER, SAMANTHA · 2023 to 2025
$149k
Determining the role of the vaginal microbiota in microbial and immunological resistance to vaginal pathobiont colonizationF31AI167538 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MEJIA, MARLYD ELIZABETH · 2022 to 2024
$143k
NIAID NIH HHS F31 AI167538NIAID NIH HHS F31 AI167547NIAID NIH HHS U19 AI157981NICHD NIH HHS F31 HD111236NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK128053NIGMS NIH HHS R25 GM056929NIGMS NIH HHS T32 GM136554NIGMS NIH HHS T32 GM152777
6 · The paper itself

Abstract

Vaginal microbial composition is associated with differential risk of urogenital infection. Although Lactobacillus spp. are thought to confer protection against infection, the lack of in vivo models resembling the human vaginal microbiota remains a prominent barrier to mechanistic discovery. Using 16S rRNA amplicon sequencing of C57BL/6J female mice, we found that vaginal microbial composition varies within and between colonies across three vivaria. Noting vaginal microbial plasticity in conventional mice, we assessed the vaginal microbiome of humanized microbiota mice (

Indexed as

Escherichia coliMicrobiotaAnimalsDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLRNA, Ribosomal, 16SStreptococcus agalactiaeVaginaRNA, Ribosomal, 16S

Identifiers

PMID37985659
PMCPMC10661851
OpenAlexW4388831311

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.