Evidence map›Paper›PMID 37986737›Full record

ArticlebioRxiv : the preprint server for biology2024

FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility.

Yuki Kaneda, Haruhiko Miyata, Zoulan Xu, Keisuke Shimada, Maki Kamoshita, Tatsuya Nakagawa, Chihiro Emori, Masahito Ikawa

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuki KanedaResearch Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 5650871 JAPAN.ORCID 0000-0001-6300-4234
Haruhiko MiyataResearch Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 5650871 JAPAN.ORCID 0000-0003-4758-5803
Zoulan XuResearch Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 5650871 JAPAN.
Keisuke ShimadaResearch Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 5650871 JAPAN.ORCID 0000-0003-3739-7163
Maki KamoshitaResearch Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 5650871 JAPAN.
Tatsuya NakagawaResearch Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 5650871 JAPAN.
Chihiro EmoriResearch Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 5650871 JAPAN.
Masahito IkawaResearch Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 5650871 JAPAN.ORCID 0000-0001-9859-6217
The University of Osaka · JPThe University of Tokyo · JP

Funding

Targeting sperm-specific proteins during meiosis and sperm morphogenesisP01HD087157 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI GARCIA, THOMAS · 2017 to 2021
$6.2M
Functional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5M
NICHD NIH HHS P01 HD087157NICHD NIH HHS R01 HD088412
6 · The paper itself

Abstract

Ribonucleoprotein (RNP) granules are membraneless electron-dense structures rich in RNAs and proteins, and involved in various cellular processes. Two RNP granules in male germ cells, intermitochondrial cement and the chromatoid body (CB), are associated with PIWI-interacting RNAs (piRNAs) and are required for transposon silencing and spermatogenesis. Other RNP granules in male germ cells, the reticulated body and CB remnants, are also essential for spermiogenesis. In this study, we disrupted FBXO24, a testis-enriched F-box protein, in mice and found numerous membraneless electron-dense granules accumulated in sperm flagella.

Indexed as

CRISPR/Cas9Ribonucleoprotein granulesSpermiogenesis

Identifiers

PMID37986737
PMCPMC10659433
OpenAlexW4388598730

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.