Evidence map›Paper›PMID 37986748›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Signatures of Cysteine Oxidation on Muscle Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults: Study of Muscle, Mobility and Aging (SOMMA).

Nicholas J Day, Shane S Kelly, Li-Yung Lui, Tyler A Mansfield, Matthew J Gaffrey, Jesse B Trejo, Tyler J Sagendorf, Kwame Attah, Ronald J Moore, Collin M Douglas and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 1 country.

Nicholas J DayBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.ORCID 0000-0003-0291-436X
Shane S KellyBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Li-Yung LuiSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Tyler A MansfieldSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Matthew J GaffreyBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Jesse B TrejoBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Tyler J SagendorfBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Kwame AttahBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Ronald J MooreBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Collin M DouglasDepartment of Physiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Anne B NewmanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-0106-1150
Stephen B KritchevskyDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Philip A KramerDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
David J MarcinekDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Paul M CoenTranslational Research Institute, AdventHealth, Orlando, Florida, USA.
Bret H GoodpasterTranslational Research Institute, AdventHealth, Orlando, Florida, USA.
Russell T HeppleDepartment of Physical Therapy, University of Florida College of Medicine, Gainesville, Florida, USA.
Peggy M CawthonSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Vladislav A PetyukBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Karyn A EsserDepartment of Physiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Wei-Jun QianBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.
Steven R CummingsSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Pacific Northwest National Laboratory · USUniversity of Florida · USAdventHealth Orlando · USCalifornia Pacific Medical Center · USUniversity of California, San Francisco · USWake Forest University · USUniversity of Pittsburgh · USUniversity of Washington · US

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI NICHOLAS Joseph SCHORK · 2004 to 2026
$102.6M
Study of Muscle, Mobility and Aging: SOMMA2R01AG059416 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STEVEN RON CUMMINGS, Peggy Mannen Cawthon · 2018 to 2026
$70.3M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LEON LENCHIK · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Study of Muscle, Mobility and Aging: SOMMA2R56AG059416 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, GOODPASTER, BRET H · 2023 to 2023
$3.1M
NCATS NIH HHS UL1 TR001420NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG059416NIA NIH HHS R56 AG059416NIA NIH HHS U19 AG023122
6 · The paper itself

Abstract

Oxidative stress is considered a contributor to declining muscle function and mobility during aging; however, the underlying molecular mechanisms remain poorly described. We hypothesized that greater levels of cysteine (Cys) oxidation on muscle proteins are associated with decreased measures of mobility. Herein, we applied a novel redox proteomics approach to measure reversible protein Cys oxidation in vastus lateralis muscle biopsies collected from 56 subjects in the Study of Muscle, Mobility and Aging (SOMMA), a community-based cohort study of individuals aged 70 years and older. We tested whether levels of Cys oxidation on key muscle proteins involved in muscle structure and contraction were associated with muscle function (leg power and strength), walking speed, and fitness (VO

Indexed as

Cysteine oxidationFitnessMusclePost-translational modificationsPowerRedox

Identifiers

PMID37986748
PMCPMC10659491
OpenAlexW4388487283

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.