Evidence map›Paper›PMID 37986906›Full record

ArticlemedRxiv : the preprint server for health sciences2023

ASSESSMENT AND CHARACTERIZATION OF COVID-19 RELATED COGNITIVE DECLINE: RESULTS FROM A NATURAL EXPERIMENT.

Zennur Sekendiz, Sean A P Clouston, Olga Morozova, Melissa A Carr, Ashley Fontana, Nikhil Mehta, Alina Ali, Eugene Jiang, Benjamin Luft

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zennur SekendizStony Brook University, Department of Medicine-World Trade Center Health Program.
Sean A P CloustonStony Brook University, Family, Population and Preventive Medicine, Program in Public Health.ORCID 0000-0002-6124-0329
Olga MorozovaThe University of Chicago, Department of Public Health Sciences.
Melissa A CarrStony Brook University, Department of Medicine-World Trade Center Health Program.
Ashley FontanaStony Brook University, Department of Medicine-World Trade Center Health Program.
Nikhil MehtaStony Brook University, Department of Medicine-World Trade Center Health Program.
Alina AliStony Brook University, Department of Medicine-World Trade Center Health Program.
Eugene JiangStony Brook University, Department of Medicine-World Trade Center Health Program.
Benjamin LuftStony Brook University, Department of Medicine-World Trade Center Health Program.
Stony Brook University · USChicago Department of Public Health · US

Funding

A lifecourse approach to PTSD and cognitive aging: A cohort of 9/11 respondersR01AG049953 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI CLOUSTON, SEAN · 2015 to 2024
$11.0M
Severity and long-term health effects of COVID-19 among World Trade Center respondersU01OH012275 · OH · STATE UNIVERSITY NEW YORK STONY BROOK · PI LUFT, BENJAMIN J · 2021 to 2025
$2.9M
NIA NIH HHS R01 AG049953NIOSH CDC HHS U01 OH012275
6 · The paper itself

Abstract

Background: Cognitive impairment is the most common and disabling manifestation of post-acute sequelae of SARS-CoV-2. There is an urgent need for the application of more stringent methods for evaluating cognitive outcomes in research studies. Objective: To determine whether cognitive decline emerges with the onset of COVID-19 and whether it is more pronounced in patients with Post-Acute Sequelae of SARS-CoV-2 or severe COVID-19. Methods: This longitudinal cohort study compared the cognitive performance of 276 patients with COVID-19 to that of 217 controls across four neuroinflammation or vascular disease-sensitive domains of cognition using data collected both before and after the pandemic starting in 2015. Results: The mean age of the COVID-19 group was 56.04±6.6 years, while that of the control group was 58.1±7.3 years. Longitudinal models indicated a significant decline in cognitive throughput (( Conclusion: COVID-19 was most likely associated with the observed cognitive decline, which was worse among patients with PASC or severe COVID-19. Monitoring patients with post-acute sequelae of SARS-CoV-2 for declines in the domains of processing speed and visual working memory and determining the long-term prognosis of this decline are therefore warranted.

Indexed as

Coronavirus disease 2019 (COVID-19)Covid-19 related Cognitive Decline (CRCD)executive dysfunctionpost-acute sequelae of SARS-CoV-2 (PASC)severe acute respiratory syndrome coronavirus 2 (SARS-COV-2)

Identifiers

PMID37986906
PMCPMC10659478
OpenAlexW4388450403

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.