Evidence map›Paper›PMID 37986947›Full record

ArticleResearch square2023

Imaging-based chromatin and epigenetic age, ImAge, quantitates aging and rejuvenation.

Martin Alvarez-Kuglen, Delany Rodriguez, Haodong Qin, Kenta Ninomiya, Lorenzo Fiengo, Chen Farhy, Wei-Mien Hsu, Aaron Havas, Gen-Sheng Feng, Amanda J Roberts and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 6 countries.

Martin Alvarez-KuglenSanford Burnham Prebys, La Jolla CA 92037, USA.ORCID https://orcid.org/0009-0002-8197-4538
Delany RodriguezSanford Burnham Prebys, La Jolla CA 92037, USA.
Haodong QinUCSD, Department of Physics, La Jolla, CA 92093, USA.
Kenta NinomiyaSanford Burnham Prebys, La Jolla CA 92037, USA.ORCID https://orcid.org/0000-0002-9566-4875
Lorenzo FiengoSanford Burnham Prebys, La Jolla CA 92037, USA.
Chen FarhySanford Burnham Prebys, La Jolla CA 92037, USA.
Wei-Mien HsuSalk Institute for Biological Studies, La Jolla, CA 92037, USA.
Aaron HavasSanford Burnham Prebys, La Jolla CA 92037, USA.ORCID https://orcid.org/0000-0003-4291-8015
Gen-Sheng FengUCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Amanda J RobertsUniversity of Wisconsin, Madison, WI 53705, USA.
Rozalyn M AndersonThe Scripps Research Institute, La Jolla, CA 92037, USA.ORCID https://orcid.org/0000-0002-0864-7998
Manuel SerranoInstitute for Research in Biomedicine (IRB Barcelona), Barcelona 08028, Spain.ORCID https://orcid.org/0000-0001-7177-9312
Peter D AdamsSanford Burnham Prebys, La Jolla CA 92037, USA.ORCID https://orcid.org/0000-0002-0684-1770
Tatyana O SharpeeSalk Institute for Biological Studies, La Jolla, CA 92037, USA.
Alexey V TerskikhSanford Burnham Prebys, La Jolla CA 92037, USA.
Sanford Burnham Prebys Medical Discovery Institute · USScripps Institution of Oceanography · USScripps Research Institute · USUniversity of Wisconsin–Madison · US

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2M
Novel Strategy to Quantitate Delayed Aging by Caloric RestrictionR21AG075483 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI TERSKIKH, ALEXEY V · 2022 to 2023
$960k
Phenotypic Screening for Longevity Interventions Using Single-cell Epigenetic SignaturesR21AG068913 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI TERSKIKH, ALEXEY V · 2020 to 2021
$536k
NCI NIH HHS P30 CA030199NIA NIH HHS R21 AG068913NIA NIH HHS R21 AG075483
6 · The paper itself

Abstract

Biomarkers of biological age that predict the risk of disease and expected lifespan better than chronological age are key to efficient and cost-effective healthcare

Identifiers

PMID37986947
PMCPMC10659560
OpenAlexW4388452766

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.