Evidence map›Paper›PMID 37987012›Full record

ArticlebioRxiv : the preprint server for biology2024

DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2.

Csenge K Rezi, Mariam G Aslanyan, Gaurav D Diwan, Tao Cheng, Mohamed Chamlali, Katrin Junger, Zeinab Anvarian, Esben Lorentzen, Kleo B Pauly, Yasmin Afshar-Bahadori and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 4 countries.

Csenge K ReziDepartment of Biology, University of Copenhagen, Denmark.
Mariam G AslanyanDepartment of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Gaurav D DiwanBioQuant, Heidelberg University, Heidelberg, Germany.
Tao ChengDepartment of Medicine (Nephrology Division) and Department of Cell Biology and Physiology, Washington University, St Louis, MO, USA.
Mohamed ChamlaliDepartment of Biology, University of Copenhagen, Denmark.
Katrin JungerInstitute for Ophthalmic Research, Eberhard Karl University of Tübingen, Tübingen, Germany.
Zeinab AnvarianDepartment of Biology, University of Copenhagen, Denmark.
Esben LorentzenDepartment of Molecular Biology and Genetics - Protein Science, Aarhus University, Denmark.ORCID 0000-0001-6493-7220
Kleo B PaulyDepartment of Biology, University of Copenhagen, Denmark.
Yasmin Afshar-BahadoriDepartment of Biology, University of Copenhagen, Denmark.
Eduardo F A FernandesCenter for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark.
Feng QianDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Sébastien TosiDanish BioImaging Infrastructure Image Analysis Core Facility (DBI-INFRA IACF), University of Copenhagen, Denmark.
Søren T ChristensenDepartment of Biology, University of Copenhagen, Denmark.ORCID 0000-0001-5004-304X
Stine F PedersenDepartment of Biology, University of Copenhagen, Denmark.ORCID 0000-0002-3044-7714
Kristian StrømgaardCenter for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark.ORCID 0000-0003-2206-4737
Robert B RussellBioQuant, Heidelberg University, Heidelberg, Germany.
Jeffrey H MinerDepartment of Medicine (Nephrology Division) and Department of Cell Biology and Physiology, Washington University, St Louis, MO, USA.ORCID 0000-0002-1510-8714
Moe R MahjoubDepartment of Medicine (Nephrology Division) and Department of Cell Biology and Physiology, Washington University, St Louis, MO, USA.ORCID 0000-0001-8129-7464
Karsten BoldtInstitute for Ophthalmic Research, Eberhard Karl University of Tübingen, Tübingen, Germany.ORCID 0000-0002-2693-689X
Ronald RoepmanDepartment of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.ORCID 0000-0002-5178-8163
Lotte B PedersenDepartment of Biology, University of Copenhagen, Denmark.ORCID 0000-0002-9749-3758
University of Copenhagen · DKWashington University in St. Louis · USHeidelberg University · DERadboud University Nijmegen · NLUniversity of Tübingen · DEAarhus University · DKUniversity of Maryland, Baltimore · US

Funding

PKD Innovation and Resource Development CoreU54DK126114 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Terry J Watnick · 2020 to 2026
$7.3M
CENTROSOME DYSFUNCTION IN POLYCYSTIC KIDNEY DISEASER01DK108005 · NIDDK · WASHINGTON UNIVERSITY · PI MAHJOUB, MOHAMED REZA · 2016 to 2020
$1.7M
NIDDK NIH HHS R01 DK108005NIDDK NIH HHS U54 DK126114Wellcome Trust
6 · The paper itself

Abstract

Polarized vesicular trafficking directs specific receptors and ion channels to cilia, but the underlying mechanisms are poorly understood. Here we describe a role for DLG1, a core component of the Scribble polarity complex, in regulating ciliary protein trafficking in kidney epithelial cells. Conditional knockout of

Indexed as

CAKUTDLG1IFT20kidney epitheliumpolycystin-2primary ciliaretromerSDCCAG3

Identifiers

PMID37987012
PMCPMC10659422
OpenAlexW4388561110

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.