Evidence map›Paper›PMID 37987328›Full record

Trial reportMedical sciences (Basel, Switzerland)2023

An Open-Label Case Series of Glutathione Use for Symptomatic Management in Children with Autism Spectrum Disorder.

Karam Radwan, Gary Wu, Kamilah Banks-Word, Ryan Rosenberger

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Medical sciences (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Karam RadwanDepartment of Psychiatry & Behavioral Neuroscience, University of Chicago Medical Center, Chicago, IL 60637, USA.ORCID 0000-0001-6966-8883
Gary WuDepartment of Psychiatry & Behavioral Sciences, Rosalind Franklin University, North Chicago, IL 60064, USA.ORCID 0000-0002-1588-9792
Kamilah Banks-WordDepartment of Psychiatry & Behavioral Neuroscience, University of Chicago Medical Center, Chicago, IL 60637, USA.
Ryan RosenbergerDepartment of Psychiatry & Behavioral Neuroscience, University of Chicago Medical Center, Chicago, IL 60637, USA.
University of Chicago Medical Center · USRosalind Franklin University of Medicine and Science · US

Funding

University of Chicago Medical Center 691694
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder that has been diagnosed in an increasing number of children around the world. The existing data suggest that early diagnosis and intervention can improve ASD outcomes. The causes of ASD remain complex and unclear, and there are currently no clinical biomarkers for autism spectrum disorder. There is an increasing recognition that ASD might be associated with oxidative stress through several mechanisms including abnormal metabolism (lipid peroxidation) and the toxic buildup of reactive oxygen species (ROS). Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. This open-label pilot study investigates the tolerability and effectiveness of oral supplementation with Opitac

Indexed as

Autism Spectrum DisorderAntioxidantsChildGlutathioneHumansOxidative StressPilot ProjectsAntioxidantsGlutathioneautismglutathioneoxidative stress in autismtranssulfuration pathway

Identifiers

PMID37987328
PMCPMC10660524
OpenAlexW4388694481

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.