Bacterial Proteases as Potentially Exploitable Modulators of SARS-CoV-2 Infection: Logic from the Literature, Informatics, and Inspiration from the Dog.

Gerald H Lushington, Annika Linde, Tonatiuh Melgarejo

Open access · goldAbstract read

In one paragraph

Article in Biotech (Basel (Switzerland)), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 46% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Global research hotspots, trends, and future directions of ivermectin research: an informatics investigation (2020-2025).Naunyn-Schmiedeberg's archives of pharmacology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Gerald H LushingtonQnapsyn Biosciences, Inc., Lawrence, KS 66046, USA.

Annika LindeCollege of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766, USA.

Tonatiuh MelgarejoCollege of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0002-3307-6218

Western University of Health Sciences · US

Funding

The study was made possible with funding from the WesternU Office for Research and Biotechnology, the College of Veterinary Medicine Office for Research, and the True One Medicine Initiative. N/A

6 · The paper itself

Abstract

(1) Background: The COVID-19 pandemic left many intriguing mysteries. Retrospective vulnerability trends tie as strongly to odd demographics as to exposure profiles, genetics, health, or prior medical history. This article documents the importance of nasal microbiome profiles in distinguishing infection rate trends among differentially affected subgroups. (2) Hypothesis: From a detailed literature survey, microbiome profiling experiments, bioinformatics, and molecular simulations, we propose that specific commensal bacterial species in the

Indexed as

Canis lupus familiariscommensal bacteriaCOVID-19Moraxellaprotease–antiprotease balancePseudomonasSARS-CoV-2serine proteasespike proteinTMPRSS2

Identifiers

PMID37987478

DOI10.3390/biotech12040061

PMCPMC10660736

OpenAlexW4388105105

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.