Evidence map›Paper›PMID 37987479›Full record

ArticleBiotech (Basel (Switzerland))2023

Tracking of Systemic Lupus Erythematosus (SLE) Longitudinally Using Biosensor and Patient-Reported Data: A Report on the Fully Decentralized Mobile Study to Measure and Predict Lupus Disease Activity Using Digital Signals-The OASIS Study.

Eldon R Jupe, Gerald H Lushington, Mohan Purushothaman, Fabricio Pautasso, Georg Armstrong, Arif Sorathia, Jessica Crawley, Vijay R Nadipelli, Bernard Rubin, Ryan Newhardt and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biotech (Basel (Switzerland)), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Eldon R JupeProgentec Diagnostics, Inc., Oklahoma City, OK 73104, USA.ORCID 0000-0001-6868-4742
Gerald H LushingtonProgentec Diagnostics, Inc., Oklahoma City, OK 73104, USA.
Mohan PurushothamanProgentec Diagnostics, Inc., Oklahoma City, OK 73104, USA.
Fabricio PautassoProgentec Diagnostics, Inc., Oklahoma City, OK 73104, USA.
Georg ArmstrongProgentec Diagnostics, Inc., Oklahoma City, OK 73104, USA.
Arif SorathiaProgentec Diagnostics, Inc., Oklahoma City, OK 73104, USA.
Jessica CrawleyProgentec Diagnostics, Inc., Oklahoma City, OK 73104, USA.
Vijay R NadipelliGSK, Philadelphia, PA 19104, USA.
Bernard RubinGSK, Raleigh, NC 27709, USA.
Ryan NewhardtProgentec Diagnostics, Inc., Oklahoma City, OK 73104, USA.
Melissa E MunroeProgentec Diagnostics, Inc., Oklahoma City, OK 73104, USA.ORCID 0000-0002-6933-9745
Brett AdelmanProgentec Diagnostics, Inc., Oklahoma City, OK 73104, USA.
GlaxoSmithKline (United States) · US

Funding

GlaxoSmithKline (United States) N/AProgentec Diagnostics Inc N/A
6 · The paper itself

Abstract

(1) Objective: Systemic lupus erythematosus (SLE) is a complex disease involving immune dysregulation, episodic flares, and poor quality of life (QOL). For a decentralized digital study of SLE patients, machine learning was used to assess patient-reported outcomes (PROs), QOL, and biometric data for predicting possible disease flares. (2) Methods: Participants were recruited from the LupusCorner online community. Adults self-reporting an SLE diagnosis were consented and given a mobile application to record patient profile (PP), PRO, and QOL metrics, and enlisted participants received smartwatches for digital biometric monitoring. The resulting data were profiled using feature selection and classification algorithms. (3) Results: 550 participants completed digital surveys, 144 (26%) agreed to wear smartwatches, and medical records (MRs) were obtained for 68. Mining of PP, PRO, QOL, and biometric data yielded a 26-feature model for classifying participants according to MR-identified disease flare risk. ROC curves significantly distinguished true from false positives (ten-fold cross-validation:

Indexed as

biosensordigitalpatient-reported outcomesreal-world evidencesigns and symptoms of flareSLE

Identifiers

PMID37987479
PMCPMC10660535
OpenAlexW4388538905

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.