Evidence map›Paper›PMID 37990460›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2023

[Expression and significance of jumonji domain-containing protein 2B and hypoxia inducible factor-1α in non-Hodgkin lymphoma tissues in children].

Yu-Qiao Diao, Jian Wang, Xiu-Li Zhu, Jian Chen, Yu Zheng, Lian Jiang, Yue-Ping Liu, Ruo-Heng Dai, Yi-Wei Yan

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yu-Qiao DiaoDepartment of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Jian WangDepartment of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Xiu-Li ZhuDepartment of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Jian ChenDepartment of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Yu ZhengDepartment of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Lian JiangDepartment of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Yue-Ping Liu
Ruo-Heng DaiDepartment of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Yi-Wei YanDepartment of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the expression and significance of jumonji domain-containing protein 2B (JMJD2B) and hypoxia-inducible factor-1α (HIF-1α) in non-Hodgkin's lymphoma (NHL) tissues in children.

methodsImmunohistochemistry was used to detect the expression of JMJD2B and HIF-1α in lymph node tissue specimens from 46 children with NHL (observation group) and 24 children with reactive hyperplasia (control group). The relationship between JMJD2B and HIF-1α expression with clinicopathological characteristics and prognosis in children with NHL, as well as the correlation between JMJD2B and HIF-1α expression in NHL tissues, were analyzed.

resultsThe positive expression rates of JMJD2B (87% vs 21%) and HIF-1α (83% vs 42%) in the observation group were higher than those in the control group (

conclusionsJMJD2B and HIF-1α are upregulated in children with NHL, and they may play a synergistic role in the development of pediatric NHL. JMJD2B can serve as a novel indicator for auxiliary diagnosis, evaluation of the severity, treatment guidance, and prognosis assessment in pediatric NHL.

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitLymphoma, Non-HodgkinChildHumansHypoxiaPrognosisHypoxia-Inducible Factor 1, alpha SubunitChildClinicopathological characteristicHypoxia-inducible factor-1αJumonji domain-containing protein 2BNon-Hodgkin's lymphomaPrognosis

Identifiers

PMID37990460
PMCPMC10672953
OpenAlexW4388922196

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.