Transcranial Alternating Current Stimulation in a Patient with Ataxia-Ocular Apraxia 2: a Case Report.

Xiao-Ping Cheng, Wen-Hui Yu, Xia Liu, Wei Lin, Zhao-Di Wang, Xi-Chen Wang, Jun Ni, Nai-Qing Cai, Xin-Yuan Chen

Abstract readCase Reports

In one paragraph

Article in Cerebellum (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiao-Ping Cheng *Department of Rehabilitation Medicine of First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.

Wen-Hui Yu *The School of Health, Fujian Medical University, Fuzhou, 350122, China.

Xia LiuDepartment of Rehabilitation Medicine of First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.

Wei LinDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, 350005, China.

Zhao-Di WangDepartment of Rehabilitation Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215008, China.

Xi-Chen WangDepartment of Rehabilitation Medicine of First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.

Jun NiDepartment of Rehabilitation Medicine of First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.

Nai-Qing CaiDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, 350005, China. cainaiqing@fjmu.edu.cn.

Xin-Yuan ChenDepartment of Rehabilitation Medicine of First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. fychenxinyuan@fjmu.edu.cn.

Funding

Fujian Medical University JKXY2023001Innovation of Science and Technology of Fujian Province 2021Y9088

6 · The paper itself

Abstract

Ataxia-ocular apraxia 2 (AOA2) is a rare neurodegenerative autosomal recessive disorder with no effective treatment. In this study, we present the case of a patient diagnosed with AOA2, who experienced walking instability and uncoordinated movement. The patient underwent transcranial alternating current stimulation (tACS) treatment for 4 weeks with follow-up after 1 month. The effectiveness of the treatment was evaluated using the International Cooperative Ataxia Rating Scale (ICARS), the Scale for the Assessment and Rating of Ataxia (SARA), the 9-Hole Peg Test (9HPT), and functional near-infrared spectroscopy (fNIRS). Following treatment, the patient's ataxia symptoms showed significant improvement and continued to be alleviated during the follow-up period, suggesting a lasting effect of tACS treatment. Our findings from this case study provide compelling evidence for the potential of tACS as a treatment option for AOA2.

Indexed as

ApraxiasCerebellar AtaxiaTranscranial Direct Current StimulationHumansHypoalbuminemiaSpinocerebellar AtaxiasTreatment OutcomeAtaxia-ocular apraxia 2;Functional near-infrared spectroscopyInternational Cooperative Ataxia Rating Scale;The 9-Hole Peg Test;The Scale for the Assessment and Rating of Ataxia;Transcranial alternating current stimulation;

Identifiers

PMID37993636

DOI10.1016/j.rehab.2017.12.002

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.