Evidence map›Paper›PMID 37994423›Full record

SynthesisRenal failure2023

Alterations of the gut microbiota in the lupus nephritis: a systematic review.

Anjing Wang, Jin Zhao, Yunlong Qin, Yumeng Zhang, Yan Xing, Yuwei Wang, Zixian Yu, Jipeng Yan, Mei Han, Jinguo Yuan and 4 more

Registry-linked trialOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Renal failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06231303 (Gut Microbiota Dysbiosis in Lupus Nephritis), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06231303 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Gut Microbiota Dysbiosis in Lupus Nephritis

TypeobservationalSponsorHager ZanatyRan2025 to 2026Enrolled60ConditionsGut Microbiota Dysbiosis in Lupus NepheritisArmsDNA extraction and PCR amplification
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Anjing WangDepartment of Postgraduate Student, Xi'an Medical University, Xi'an, China.
Jin ZhaoDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yunlong QinDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yumeng ZhangDepartment of Postgraduate Student, Xi'an Medical University, Xi'an, China.
Yan XingDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yuwei WangDepartment of Postgraduate Student, Xi'an Medical University, Xi'an, China.
Zixian YuDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Jipeng YanDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Mei HanDepartment of Postgraduate Student, Xi'an Medical University, Xi'an, China.
Jinguo YuanDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yueqing HuiDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Shuxian GuoDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Xiaoxuan NingDepartment of Geriatric, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Shiren SunDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Xijing Hospital · CNAir Force Medical University · CNXi'an Medical University · CNBethune International Peace Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmerging evidence suggests that gut microbiota dysbiosis may play a critical role in the development of lupus nephritis (LN). However, the specific characteristics of the gut microbiota in individuals with LN have not been fully clarified.

methodsThe PubMed, Web of Science, and Embase databases were systematically searched for clinical and animal studies related to the relationship between LN and gut microbiota from inception until October 1, 2023. A semiquantitative analysis was used to assess the changes in gut microbial profiles.

resultsA total of 15 clinical studies were selected for analysis, which included 138 LN patients, 441 systemic lupus erythematosus patients, and 1526 healthy controls (HCs). Five different types of LN mouse models were included in 5 animal studies. The alpha diversity was decreased in LN patients compared to HCs. A significant decrease in the

conclusionsSpecific changes in the abundance of gut microbiota such as decreased F/B ratio, and the level of inflammatory indicators, and markers of intestinal barrier dysfunction may play a crucial role in the pathogenesis of LN. These factors could be effective diagnostic and potential therapeutic targets for LN.

Indexed as

Gastrointestinal MicrobiomeIntestinal DiseasesLupus Erythematosus, SystemicLupus NephritisAnimalsHumansInterleukin-6MiceInterleukin-6Gut microbiotaLupus nephritisSystematic reviewSystemic lupus erythematosus

Identifiers

PMID37994423
PMCPMC11001323
OpenAlexW4388928878

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.