Evidence map›Paper›PMID 37998125›Full record

ArticleBiosensors2023

Topoisomerase 1 Activity Is Reduced in Response to Thermal Stress in Fruit Flies and in Human HeLa Cells.

Trine Juul-Kristensen, Josephine Geertsen Keller, Kathrine Nygaard Borg, Noriko Y Hansen, Amalie Foldager, Rasmus Ladegaard, Yi-Ping Ho, Volker Loeschcke, Birgitta R Knudsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Trine Juul-KristensenDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Josephine Geertsen KellerDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0003-0567-3653
Kathrine Nygaard BorgDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.ORCID 0009-0003-0414-3017
Noriko Y HansenDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Amalie FoldagerDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.ORCID 0009-0007-7557-0592
Rasmus LadegaardDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Yi-Ping HoDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-2052-9724
Volker LoeschckeDepartment of Biology, Aarhus University, 8000 Aarhus, Denmark.
Birgitta R KnudsenDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Aarhus University · DKChinese University of Hong Kong · HKCity University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the modern world with climate changes and increasing pollution, different types of stress are becoming an increasing challenge. Hence, the identification of reliable biomarkers of stress and accessible sensors to measure such biomarkers are attracting increasing attention. In the current study, we demonstrate that the activity, but not the expression, of the ubiquitous enzyme topoisomerase 1 (TOP1), as measured in crude cell extracts by the REEAD sensor system, is markedly reduced in response to thermal stress in both fruit flies (

Indexed as

Drosophila melanogasterAnimalsBiomarkersHeLa CellsHumansBiomarkersbiomarkerbiosensorenzyme activitythermal stresstopoisomerase 1

Identifiers

PMID37998125
PMCPMC10669382
OpenAlexW4387909303

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.