Evidence map›Paper›PMID 37998817›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Protective Effect of Procyanidin-Rich Grape Seed Extract against Gram-Negative Virulence Factors.

Roberta Maria Nicolosi, Graziana Bonincontro, Elena Imperia, Camilla Badiali, Daniela De Vita, Fabio Sciubba, Laura Dugo, Michele Pier Luca Guarino, Annamaria Altomare, Giovanna Simonetti and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. The Effects of a Prebiotic Formula PromotingInternational journal of medical sciences · 2026
    Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Polyphenol Analysis and Antibacterial Potentials of Twig Extracts ofInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Roberta Maria NicolosiDepartment of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Graziana BonincontroDepartment of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Elena ImperiaDepartment of Science and Technology for Sustainable Development and One Health, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy.
Camilla BadialiDepartment of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-9243-5903
Daniela De VitaDepartment of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Fabio SciubbaDepartment of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-1982-2712
Laura DugoDepartment of Science and Technology for Sustainable Development and One Health, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy.ORCID 0000-0001-5527-0364
Michele Pier Luca GuarinoResearch Unit of Gastroenterology, Department of Medicine and Surgery, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy.
Annamaria AltomareDepartment of Science and Technology for Sustainable Development and One Health, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy.ORCID 0000-0001-8630-7836
Giovanna SimonettiDepartment of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-4321-4626
Gabriella PasquaDepartment of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-3823-7284
Sapienza University of Rome · ITUniversità Campus Bio-Medico · IT

Funding

POR FESR Lazio 2014-2020 - Azione 1.2.1 PROT. A0375-2020-36590- "Gruppi di ricerca 2020". PROT. A0375-2020-36590progetto Ateneo RM120172A34CFCC9
6 · The paper itself

Abstract

Biofilm formation and lipopolysaccharide (LPS) are implicated in the pathogenesis of gastrointestinal (GI) diseases caused by Gram-negative bacteria. Grape seeds, wine industry by-products, have antioxidant and antimicrobial activity. In the present study, the protective effect of procyanidin-rich grape seed extract (prGSE), from unfermented pomace of

Indexed as

anti-virulence factorsbacterial biofilmCaco-2Escherichia coliGalleria mellonellagrape seed extractLPSSalmonella enterica subsp. enterica serovar TyphimuriumVitis vinifera L.

Identifiers

PMID37998817
PMCPMC10668874
OpenAlexW4388634382

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.