ArticleeLife2023
Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Pooled it
- Sleep-Related Respiratory Disruption is Associated with Altered Spindle Morphology and Poorer Attention in Children.bioRxiv : the preprint server for biology · 2026Article
- Differences in sleep spindles and polysomnography in humans: a meta-analysis on the influence of age, sex, and cognitive ability.Frontiers in sleep · 2026Review
- Capturing individual variation in children's electroencephalograms during nREM sleep.PLoS computational biology · 2026Article
- Using a wearable EEG device to examine age trends in sleep macro- and micro-architecture across adolescence.bioRxiv : the preprint server for biology · 2025Article
- Competitive roles of slow/delta oscillation-nesting-mediated sleep disruption under acute methamphetamine exposure in monkeys.Journal of Zhejiang University. Science. B · 2025Article
- Differences in brain spindle density during sleep between patients with and without type 2 diabetes.Computers in biology and medicine · 2025Article
- Slow-wave sleep as a key player in offline memory processing: insights from human EEG studies.Frontiers in behavioral neuroscience · 2025Review
- Differences in sleep spindle wave density between patients with diabetes mellitus and matched controls: implications for sensing and regulation of peripheral blood glucose.medRxiv : the preprint server for health sciences · 2024Article
- Development of slow oscillation-spindle coupling from infancy to toddlerhood.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Sleep-dependent memory consolidation in young and aged brains.Aging brain · 2024Article
- Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development.eLife · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
Abstract
The synchronization of canonical fast sleep spindle activity (12.5-16 Hz, adult-like) precisely during the slow oscillation (0.5-1 Hz) up peak is considered an essential feature of adult non-rapid eye movement sleep. However, there is little knowledge on how this well-known coalescence between slow oscillations and sleep spindles develops. Leveraging individualized detection of single events, we first provide a detailed cross-sectional characterization of age-specific patterns of slow and fast sleep spindles, slow oscillations, and their coupling in children and adolescents aged 5-6, 8-11, and 14-18 years, and an adult sample of 20- to 26-year-olds. Critically, based on this, we then investigated how spindle and slow oscillation maturity substantiate age-related differences in their precise orchestration. While the predominant type of fast spindles was development-specific in that it was still nested in a frequency range below the canonical fast spindle range for the majority of children, the well-known slow oscillation-spindle coupling pattern was evident for sleep spindles in the adult-like canonical fast spindle range in all four age groups-but notably less precise in children. To corroborate these findings, we linked personalized measures of fast spindle maturity, which indicate the similarity between the prevailing development-specific and adult-like canonical fast spindles, and slow oscillation maturity, which reflects the extent to which slow oscillations show frontal dominance, with individual slow oscillation-spindle coupling patterns. Importantly, we found that fast spindle maturity was uniquely associated with enhanced slow oscillation-spindle coupling strength and temporal precision across the four age groups. Taken together, our results suggest that the increasing ability to generate adult-like canonical fast sleep spindles actuates precise slow oscillation-spindle coupling patterns from childhood through adolescence and into young adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.