Evidence map›Paper›PMID 38001818›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Differential Modulation of Markers of Oxidative Stress and DNA Damage in Arterial Hypertension.

Moritz Kreutzmann, Bettina J Kraus, Martin Christa, Stefan Störk, Eugène H J M Jansen, Helga Stopper, Nicole Schupp

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Moritz KreutzmannInstitute of Toxicology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany.
Bettina J KrausDepartment of Clinical Research & Epidemiology, Comprehensive Heart Failure Centre, University Hospital Würzburg, 97078 Würzburg, Germany.
Martin ChristaDepartment of Clinical Research & Epidemiology, Comprehensive Heart Failure Centre, University Hospital Würzburg, 97078 Würzburg, Germany.ORCID 0000-0002-8703-7644
Stefan StörkDepartment of Clinical Research & Epidemiology, Comprehensive Heart Failure Centre, University Hospital Würzburg, 97078 Würzburg, Germany.ORCID 0000-0002-1771-7249
Eugène H J M JansenCentre for Health Protection, National Institute for Public Health and the Environment, 3721 MA Bilthoven, The Netherlands.ORCID 0000-0002-3151-5897
Helga StopperInstitute of Pharmacology and Toxicology, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0003-4168-8211
Nicole SchuppInstitute of Toxicology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-1836-6348
Universitätsklinikum Würzburg · DEHeinrich Heine University Düsseldorf · DEBoehringer Ingelheim (Germany) · DENational Institute for Public Health and the Environment · NL

Funding

Wellcome Trust 109328
6 · The paper itself

Abstract

Patients with arterial hypertension have an increased risk of developing tumors, particularly renal cell carcinoma. Arterial hypertension is linked to DNA damage via the generation of oxidative stress, in which an upregulated renin-angiotensin-aldosterone system plays a crucial role. The current study investigated surrogates of oxidative stress and DNA damage in a group of hypertensive patients (HypAll, n = 64) and subgroups of well (HypWell, n = 36) and poorly (HypPoor, n = 28) controlled hypertensive patients compared to healthy controls (n = 8). In addition, a longitudinal analysis was performed with some of the hypertensive patients. Markers for oxidative stress in plasma (SHp, D-ROM, and 3-nitrotyrosine) and urine (8-oxodG, 15-F

Indexed as

3-nitrotyrosine8-oxodGhigh blood pressureSHpγ-H2AX

Identifiers

PMID38001818
PMCPMC10669810
OpenAlexW4388333408

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.