Evidence map›Paper›PMID 38004213›Full record

ReviewNutrients2023

Association between Average Vitamin D Levels and COVID-19 Mortality in 19 European Countries-A Population-Based Study.

Amar S Ahmad, Nirmin F Juber, Heba Al-Naseri, Christian Heumann, Raghib Ali, Tim Oliver

Abstract readReview
In one paragraph

Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amar S AhmadCancer Intelligence, Cancer Research UK, London E20 1JQ, UK.
Nirmin F JuberPublic Health Research Center, New York University Abu Dhabi, Abu Dhabi P.O. Box 129188, United Arab Emirates.ORCID 0000-0002-7316-5530
Heba Al-NaseriAcademic Unit of Medical Education, University of Southampton, Southampton SO17 1BJ, UK.
Christian HeumannDepartment of Statistics, Ludwig Maximilian University of Munich, 80539 München, Germany.ORCID 0000-0002-4718-595X
Raghib AliMRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0SL, UK.
Tim OliverBarts Cancer Institute, Queen Mary University of London, London EC1M 6AU, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early epidemic reports have linked low average 25(OH) vitamin D levels with increased COVID-19 mortality. However, there has been limited updated research on 25(OH) vitamin D and its impact on COVID-19 mortality. This study aimed to update the initial report studying the link between vitamin D deficiency and COVID-19 mortality by using multi-country data in 19 European countries up to the middle of June 2023. COVID-19 data for 19 European countries included in this study were downloaded from Our World in Data from 1 March 2020, to 14 June 2023, and were included in the statistical analysis. The 25(OH) vitamin D average data were collected by conducting a literature review. A generalized estimation equation model was used to model the data. Compared to European countries with 25(OH) vitamin D levels of ≤50 nmol/L, European countries with 25(OH) vitamin D average levels greater than 50 nmol/L had lower COVID-19 mortality rates (RR = 0.794, 95% CI: 0.662-0.953). A statistically significant negative Spearman rank correlation was observed between 25(OH) vitamin D average levels and COVID-19 mortality. We also found significantly lower COVID-19 mortality rates in countries with high average 25(OH) vitamin D levels. Randomized trials on vitamin D supplementation are needed. In the meantime, the issue of vitamin D use should be debated in relation to the ongoing discussions of national post-COVID-19 resilience against future pandemics.

Indexed as

COVID-19Vitamin D DeficiencyHumansResearch DesignVitamin DVitaminsVitamin DVitaminscoronavirusCOVID-19Europegeneralized estimation equation modelmortalitypopulation-based studyvitamin D

Identifiers

PMID38004213
PMCPMC10680994

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.