Evidence map›Paper›PMID 38004262›Full record

ArticleLife (Basel, Switzerland)2023

Examining the Aryl Hydrocarbon Receptor Network in the Placental Tissues of Pregnancies Complicated by Pre-Eclampsia: An Explorative Case-Control Analysis.

Serena Xodo, Ambrogio P Londero, Maria Orsaria, Stefania Marzinotto, Gianluca Colussi, Angelo Cagnacci, Laura Mariuzzi, Giorgia Gri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Serena XodoClinic of Obstetrics and Gynecology, "Azienda Sanitaria Universitaria Integrata di Udine", DAME, University of Udine, 33100 Udine, Italy.ORCID 0000-0001-9756-0511
Ambrogio P LonderoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Infant Health, University of Genoa, 16132 Genova, Italy.ORCID 0000-0001-6429-1220
Maria OrsariaInstitute of Pathology, "Azienda Sanitaria Universitaria Integrata di Udine", DAME, University of Udine, 33100 Udine, Italy.ORCID 0000-0001-9978-8130
Stefania MarzinottoInstitute of Pathology, "Azienda Sanitaria Universitaria Integrata di Udine", DAME, University of Udine, 33100 Udine, Italy.
Gianluca ColussiHypertension Unit, Department of Medicine, ASFO "Santa Maria degli Angeli" Hospital of Pordenone, 33170 Pordenone, Italy.ORCID 0000-0003-1673-540X
Angelo CagnacciDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Infant Health, University of Genoa, 16132 Genova, Italy.ORCID 0000-0003-2714-623X
Laura MariuzziInstitute of Pathology, "Azienda Sanitaria Universitaria Integrata di Udine", DAME, University of Udine, 33100 Udine, Italy.ORCID 0000-0002-1243-8398
Giorgia GriDIMEC-Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-2826-0459
University of Udine · ITAzienda Ospedaliera Santa Maria Degli Angeli · ITIstituto Giannina Gaslini · ITOspedale Policlinico San Martino · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe maternal and newborn morbidity and mortality associated with pre-eclampsia, which are caused partly by premature delivery, affect a factual proportion of pregnancies. Despite its prevalence, the underlying causes of pre-eclampsia remain elusive, with emerging evidence implicating the aryl hydrocarbon receptor (AhR) in its pathogenesis. This study sought to elucidate the involvement of the AhR and its associated pathway in pre-eclampsia by comparing placental components of the AhR pathway in pregnant individuals with and without pre-eclampsia. This case-control investigation was conducted at the University Hospital of Udine from May 2021 to February 2023. The AhR was assessed using immunohistochemistry and immunofluorescence, and its mRNA was evaluated using a Real-Time Quantitative Reverse Transcription PCR. Levels of mRNA expression were also estimated for other components of the AhR pathway (CYP1B1, IDO1, ARNT, TIPARP, S100A4, and AHRR). Our findings show decreased levels of expression of AhR, IDO1, ARNT, TiPARP, and S100A4 in the placental tissues of individuals with pre-eclampsia compared to controls (

Indexed as

AhRaryl hydrocarbon receptorCYP1B1IDO1pre-eclampsiaS100A4TiPARP

Identifiers

PMID38004262
PMCPMC10672047
OpenAlexW4387957443

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.