Evidence map›Paper›PMID 38005994›Full record

ArticleVaccines2023

In Vivo Treatment with Insulin-like Growth Factor 1 Reduces CCR5 Expression on Vaccine-Induced Activated CD4

Massimiliano Bissa, Veronica Galli, Luca Schifanella, Monica Vaccari, Mohammad Arif Rahman, Giacomo Gorini, Nicolò Binello, Sarkis Sarkis, Anna Gutowska, Isabela Silva de Castro and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 1 country.

Massimiliano BissaAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0003-3455-3992
Veronica GalliAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
Luca SchifanellaAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
Monica VaccariAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
Mohammad Arif RahmanAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0002-6120-8943
Giacomo GoriniAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
Nicolò BinelloAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
Sarkis SarkisAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
Anna GutowskaAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0002-9873-6432
Isabela Silva de CastroAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
Melvin N DosterAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
Ramona MolesAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
Guido FerrariDivision of Surgical Sciences, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Xiaoying ShenDivision of Surgical Sciences, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Georgia D TomarasDivision of Surgical Sciences, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
David C MontefioriDivision of Surgical Sciences, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Kombo F N'guessanUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Dominic Paquin-ProulxUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0003-1407-3414
Pamela A KozlowskiDepartment of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.ORCID 0000-0001-9906-6234
David J VenzonBiostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0002-8990-158X
Hyoyoung Choo-WosobaBiostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Matthew W BreedLaboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD 21701, USA.
Joshua KramerLaboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD 21701, USA.
Genoveffa FranchiniAnimal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.
National Cancer Institute · USDuke University · USHenry M. Jackson Foundation · USLeidos (United States) · USLouisiana State University Health Sciences Center New Orleans · USTulane University · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
Resource for Nonhuman Primate Cell Depleting AntibodiesR24OD010976 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ENGELMAN, KATHLEEN, MAGNANI, DIOGO · 2012 to 2019
$4.7M
NCI NIH HHS Intramural fundsNIAID NIH HHS HHSN272201800004CNIAID NIH HHS U24 AI126683NIH HHS P51 OD011104NIH HHS R24 OD010976
6 · The paper itself

Abstract

At the heart of the DNA/ALVAC/gp120/alum vaccine's efficacy in the absence of neutralizing antibodies is a delicate balance of pro- and anti-inflammatory immune responses that effectively decreases the risk of SIV

Indexed as

CCR5CD4HIVIGF-1insulin-like growth factorSIVT-cells

Identifiers

PMID38005994
PMCPMC10675829
OpenAlexW4388094441

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.