ArticlebioRxiv : the preprint server for biology2024
Atypical Protein Kinase C Promotes its own Asymmetric Localisation by Phosphorylating Cdc42 in the
John Packer, Alicia G Gubieda, Aaron Brooks, Lars N Deutz, Iolo Squires, Shona Ellison, Claudia Schneider, Sundar Ram Naganathan, Adam J M Wollman, Daniel J Dickinson and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 5 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors at 4 institutions in 3 countries.
John PackerNewcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Alicia G GubiedaNewcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Aaron BrooksNewcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Lars N DeutzDepartment of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA.
Iolo SquiresNewcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Shona EllisonThe Francis Crick Institute, London, NW1 1AT, UK.
Claudia SchneiderNewcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Sundar Ram NaganathanDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Adam J M WollmanNewcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Daniel J DickinsonDepartment of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA.ORCID 0000-0003-2651-2584 Josana RodriguezNewcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.ORCID 0000-0001-8800-1283 Newcastle University · GBTata Institute of Fundamental Research · INThe University of Texas at Austin · USThe Francis Crick Institute · GB
Funding
Understanding developmental control of cell polarity using single-cell in vivo biochemistryR01GM138443 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI DICKINSON, DANIEL J · 2020 to 2025
$2.4MNIGMS NIH HHS R01 GM138443Wellcome Trust CC2068Wellcome Trust CC2119
6 · The paper itselfAbstract
Atypical protein kinase C (aPKC) is a major regulator of cell polarity. Acting in conjunction with Par6, Par3 and the small GTPase Cdc42, aPKC becomes asymmetrically localised and drives the polarisation of cells. aPKC activity is crucial for its own asymmetric localisation, suggesting a hitherto unknown feedback mechanism contributing to polarisation. Here we show in the
Indexed as
actomyosin cortex dynamicsaPKCaPKC self-regulatory feedbackasymmetric cell divisionatypical protein kinase Ccell patterningcell polarityembryo axismembrane protein complex dynamicsPAR proteinsphosphoregulation of CDC-42
Identifiers
PMID38009101
PMCPMC10675845
OpenAlexW4388179024
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
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