ArticleClinical research in cardiology : official journal of the German Cardiac Society2024
Refining accuracy of RV-PA coupling in patients undergoing transcatheter tricuspid valve treatment.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Right ventricle to pulmonary artery coupling as a prognostic factor in tricuspid regurgitation: A systematic review.ESC heart failure · 2025Pooled it
- The prognostic role of right ventricular-pulmonary arterial coupling in aortic stenosis patients undergoing TAVR: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Right Ventricular Function in Patients With Significant Tricuspid Regurgitation.Reviews in cardiovascular medicine · 2026Review
- EACVI Survey on the Current Multi-Modality Imaging Practice in Patients with Tricuspid Regurgitation.European heart journal. Imaging methods and practice · 2026Article
- Echocardiographic and invasive RV-PA coupling predict mortality after edge-to-edge repair for degenerative mitral regurgitation, while pulmonary artery pulsatility index does not: a single-center observational study.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Indication and timing in tricuspid interventions.Journal of echocardiography · 2025Review
- Echocardiographic Imaging to Guide Tricuspid Interventions.Structural heart : the journal of the Heart Team · 2025Review
- Efficacy and Safety of Transcatheter Tricuspid Valve Replacement in Patients With Moderate to Severe Tricuspid Regurgitation: A Systematic Review and Meta-Analysis on Clinical Outcomes and Echocardiographic Indices.Health science reports · 2025Review
- Transcatheter Tricuspid Valve Replacement: Current Options and Future Perspectives.Reviews in cardiovascular medicine · 2025Review
- Invasive Assessment of Right Ventricular to Pulmonary Artery Coupling Improves 1-year Mortality Prediction After Transcatheter Aortic Valve Replacement and Anticipates the Persistence of Extra-Aortic Valve Cardiac Damage.Structural heart : the journal of the Heart Team · 2024Article
- Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart disease.Frontiers in cardiovascular medicine · 2024Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssessing right ventricular (RV) function is paramount for risk stratification, which remains challenging in patients with tricuspid regurgitation (TR). We assessed RV-pulmonary artery (PA) coupling and its predictability of outcomes after transcatheter tricuspid valve repair (TTVR).
methodsStudy participants comprised patients undergoing transcatheter tricuspid valve repair to treat symptomatic TR from June 2015 to July 2021. We calculated an RV-PA coupling ratio using a formula, which is dividing tricuspid annular plane systolic excursion (TAPSE) by echocardiographically estimated (ePASP) or invasively measured PASP (iPASP) at baseline. The primary outcome was all-cause mortality or heart failure rehospitalization within one year.
resultsThe study participants (n = 206) were at high surgical risk (EuroSCORE II: 7.4 ± 4.8%). The primary outcome occurred in 57 patients within one year. The c-statistics for the outcome were 0.565 (95% CI 0.488-0.643) for TAPSE/ePASP and 0.695 (95% CI 0.631-0.759) for TAPSE/iPASP. The correlation between the ePASP and iPASP was attenuated in patients with massive/torrential TR compared to those with severe TR (interaction p = 0.01). In the multivariable Cox proportional model, TAPSE/iPASP was inversely associated with the risk of the primary outcome (per 0.1-point increase: adjusted-HR 0.67, 95% CI 0.56-0.82, p < 0.001), independent of baseline demographics. According to the TAPSE/iPASP quartiles (i.e., ≤ 0.316; 0.317-0.407; 0.408-0.526; ≥ 0.527), the event-free survival was 43.4%, 48.3%, 77.9%, and 85.4% at one year after TTVR.
conclusionRV-PA coupling predicts one-year mortality and heart failure rehospitalization after TTVR in patients with TR. The predictability is improved if invasively-measured PA pressure is included.
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