Trial reportAnnals of internal medicine2023
Blood Pressure Effect of Traffic-Related Air Pollution : A Crossover Trial of In-Vehicle Filtration.
Trial report in Annals of internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05454930 (Effect of Commute Traffic on Vascular Function), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Commute Traffic on Vascular Function
Who cites it
8 citing papers in PubMed.
- Health Benefits of Air Purification: A Systematic Review.Environment & health (Washington, D.C.) · 2026Review
- Particulate Matter concentration measurement in ambient air: analysis of filter material and recovery time variables for uncertainty assessment.Environmental monitoring and assessment · 2026Article
- Breathing Easier: Air Filtration to Improve Indoor Air Quality as a Cardiovascular Intervention.Journal of the American College of Cardiology · 2025Article
- Seasonal Characterization of Primary and Secondary Sources of Fine PM-Bound Water-Soluble Organic Carbon in Central Los Angeles.Atmospheric environment (Oxford, England : 1994) · 2025Article
- Climate change and cardiovascular health: Recent updates and actions for healthcare.American heart journal plus : cardiology research and practice · 2024Article
- A Single Bout of Prolonged Sitting Augments Very Short-Term Blood Pressure Variability.American journal of hypertension · 2024Article
- Primary Prevention of Coronary and Other Cardiovascular Diseases: A Focused Review.Journal of atherosclerosis and thrombosis · 2024Review
- Personal Strategies to Reduce the Cardiovascular Impacts of Environmental Exposures.Circulation research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundAmbient air pollution, including traffic-related air pollution (TRAP), increases cardiovascular disease risk, possibly through vascular alterations. Limited information exists about in-vehicle TRAP exposure and vascular changes.
objectiveTo determine via particle filtration the effect of on-roadway TRAP exposure on blood pressure and retinal vasculature.
designRandomized crossover trial. (ClinicalTrials.gov: NCT05454930).
settingIn-vehicle scripted commutes driven through traffic in Seattle, Washington, during 2014 to 2016.
participantsNormotensive persons aged 22 to 45 years (
interventionOn 2 days, on-road air was entrained into the vehicle. On another day, the vehicle was equipped with high-efficiency particulate air (HEPA) filtration. Participants were blinded to the exposure and were randomly assigned to the sequence. MEASUREMENTS: Fourteen 3-minute periods of blood pressure were recorded before, during, and up to 24 hours after a drive. Image-based central retinal arteriolar equivalents (CRAEs) were measured before and after. Brachial artery diameter and gene expression were also measured and will be reported separately.
resultsMean age was 29.7 years, predrive systolic blood pressure was 122.7 mm Hg, predrive diastolic blood pressure was 70.8 mm Hg, and drive duration was 122.3 minutes (IQR, 4 minutes). Filtration reduced particle count by 86%. Among persons with complete data ( LIMITATIONS: Imprecise estimates due to small sample size; seasonal imbalance by exposure order.
conclusionFiltration of TRAP may mitigate its adverse effects on blood pressure rapidly and at 24 hours. Validation is required in larger samples and different settings. PRIMARY FUNDING SOURCE: U.S. Environmental Protection Agency and National Institutes of Health.
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