Evidence map›Paper›PMID 38011999›Full record

ArticleLife science alliance2024

RNA helicase EIF4A1-mediated translation is essential for the GC response.

Michael Screen, Louise S Matheson, Andrew Jm Howden, Douglas Strathdee, Anne E Willis, Martin Bushell, Owen Sansom, Martin Turner

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Michael ScreenImmunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, UK michael.screen@babraham.ac.uk.ORCID 0000-0002-6290-9215
Louise S MathesonImmunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, UK.
Andrew Jm HowdenCell Signalling and Immunology, University of Dundee, Dundee, UK.
Douglas StrathdeeCancer Research UK Beatson Institute, Glasgow, UK.
Anne E WillisMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Martin BushellCancer Research UK Beatson Institute, Glasgow, UK.
Owen SansomCancer Research UK Beatson Institute, Glasgow, UK.
Martin TurnerImmunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, UK martin.turner@babraham.ac.uk.ORCID 0000-0002-3801-9896
Babraham Institute · GBCancer Research UK Scotland Institute · GBUniversity of Cambridge · GBUniversity of Dundee · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/B/000C0407Cancer Research UK 24388Cancer Research UK 29252Cancer Research UK 30062Cancer Research UK SICR_CORE_TRANST_2324Medical Research Council MC_UU_00025/7Wellcome Trust 200823/Z/16/Z
6 · The paper itself

Abstract

EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5' untranslated regions. However, very little is known of their roles in nonmalignant cells. Using mouse models to delete

Indexed as

B-LymphocytesEukaryotic Initiation Factor-4ARNA HelicasesAnimalsMiceEukaryotic Initiation Factor-4ARNA Helicases

Identifiers

PMID38011999
PMCPMC10681908
OpenAlexW4389043408

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.