Evidence map›Paper›PMID 38012000›Full record

ArticleLife science alliance2024

A dual-targeted drug inhibits cardiac ryanodine receptor Ca

Jörg W Wegener, Gyuzel Y Mitronova, Lina ElShareif, Christine Quentin, Vladimir Belov, Tatiana Pochechueva, Gerd Hasenfuss, Lutz Ackermann, Stephan E Lehnart

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Development of activators for SERCA2a for heart failure treatments.European journal of medicinal chemistry · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jörg W WegenerDepartment of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany joerg.wegener@med.uni-goettingen.de.ORCID 0000-0002-8129-1537
Gyuzel Y MitronovaDepartment of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0003-4376-6981
Lina ElShareifDepartment of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany.ORCID 0009-0000-4857-1994
Christine QuentinDepartment of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0001-9101-3488
Vladimir BelovDepartment of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Tatiana PochechuevaDepartment of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany.ORCID 0000-0002-3382-4669
Gerd HasenfussDepartment of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany.ORCID 0000-0002-5942-361X
Lutz AckermannGeorg-August University of Göttingen, Institute of Organic and Biomolecular Chemistry, Göttingen, Germany.
Stephan E LehnartDepartment of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany slehnart@med.uni-goettingen.de.ORCID 0000-0002-8115-3513
German Centre for Cardiovascular Research · DEMax Planck Institute for Multidisciplinary Sciences

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the heart, genetic or acquired mishandling of diastolic [Ca

Indexed as

DantroleneRyanodine Receptor Calcium Release ChannelAnimalsArrhythmias, CardiacBiological TransportHumansMiceMyocytes, CardiacDantroleneRyanodine Receptor Calcium Release Channel

Identifiers

PMID38012000
PMCPMC10681910
OpenAlexW4389058760

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.