Evidence map›Paper›PMID 38012018›Full record

ArticleHuman vaccines & immunotherapeutics2023

Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models.

Viviane M Andrade, Igor Maricic, Richa Kalia, Lauren Jachimowicz, Olivia Bedoya, Daniel W Kulp, Laurent Humeau, Trevor R F Smith

Open access · goldAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. A comprehensive comparison of DNA and RNA vaccines.Advanced drug delivery reviews · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Viviane M AndradePreclinical R&D, Inovio Pharmaceuticals Inc, San Diego, CA, USA.ORCID 0000-0002-5056-298X
Igor MaricicPreclinical R&D, Inovio Pharmaceuticals Inc, San Diego, CA, USA.
Richa KaliaPreclinical R&D, Inovio Pharmaceuticals Inc, San Diego, CA, USA.
Lauren JachimowiczPreclinical R&D, Inovio Pharmaceuticals Inc, San Diego, CA, USA.
Olivia BedoyaPreclinical R&D, Inovio Pharmaceuticals Inc, San Diego, CA, USA.
Daniel W KulpVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
Laurent HumeauPreclinical R&D, Inovio Pharmaceuticals Inc, San Diego, CA, USA.
Trevor R F SmithPreclinical R&D, Inovio Pharmaceuticals Inc, San Diego, CA, USA.ORCID 0000-0002-0671-2565
Inovio Pharmaceuticals (United States) · USThe Wistar Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleic acid vaccines are designed based on genetic sequences (DNA or mRNA) of a target antigen to be expressed

Indexed as

COVID-19Vaccines, DNAAnimalsAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesCricetinaeDNAGuinea PigsHumansImmunityMiceModels, AnimalPandemicsRabbitsRNA, MessengerAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesDNARNA, MessengerSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Vaccines, DNAanimal modelsCOVID-19DNA vaccinesimmunogenicitymRNA vaccinesSARS-CoV-2

Identifiers

PMID38012018
PMCPMC10760386
OpenAlexW4389068758

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.