Evidence map›Paper›PMID 38012156›Full record

ArticleBlood cancer journal2023

SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm.

Yue Yang, Salar Abbas, Mohammad A Sayem, Avik Dutta, Golam Mohi

Open access · goldAbstract read
In one paragraph

Article in Blood cancer journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  5. The Role and Impact of Non-driver Gene Mutations in Myelofibrosis.Current hematologic malignancy reports · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yue YangDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Salar AbbasDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.ORCID 0000-0001-8383-4876
Mohammad A SayemDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.ORCID 0000-0001-9903-6959
Avik DuttaDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.ORCID 0000-0002-0368-2858
Golam MohiDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA. gm7sj@virginia.edu.ORCID 0000-0002-7530-4784
University of Virginia · USUniversity of Virginia Cancer Center

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1M
Role of JAK2V617F in the Pathogenesis of Myeloproliferative NeoplasmsR01HL095685 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI MOHI, GOLAM · 2009 to 2018
$3.8M
Molecular Basis for Myelodysplasia Induced by U2AF1 MutationsR01HL168611 · NHLBI · UNIVERSITY OF VIRGINIA · PI Golam Mohi · 2023 to 2026
$2.3M
The Role of PTPN11 in MyelofibrosisR01HL149893 · NHLBI · UNIVERSITY OF VIRGINIA · PI MOHI, GOLAM · 2020 to 2023
$1.6M
NCI NIH HHS P30 CA044579NHLBI NIH HHS R01 HL095685NHLBI NIH HHS R01 HL149893NHLBI NIH HHS R01 HL168611
6 · The paper itself

Abstract

SRSF2 mutations are found in association with JAK2V617F in myeloproliferative neoplasms (MPN), most frequently in myelofibrosis (MF). However, the contribution of SRSF2 mutation in JAK2V617F-driven MPN remains elusive. To investigate the consequences of SRSF2

Indexed as

Myeloproliferative DisordersNeoplasmsPolycythemiaSerine-Arginine Splicing FactorsAnimalsJanus Kinase 2MiceMutationPrimary MyelofibrosisJanus Kinase 2Serine-Arginine Splicing FactorsSRSF2 protein, mouse

Identifiers

PMID38012156
PMCPMC10682023
OpenAlexW4389051796

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.