Evidence map›Paper›PMID 38012158›Full record

ArticleTranslational psychiatry2023

Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking.

Patrick J Mulholland, Audrey E Padula, Larry J Wilhelm, Byung Park, Kathleen A Grant, Betsy M Ferguson, Rita Cervera-Juanes

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. KAlcohol (Fayetteville, N.Y.) · 2025
    Article
  3. Adaptations in glutathione-based redox protein signaling pathways and alcohol drinking across species.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Patrick J MulhollandDepartment of Neuroscience, Charleston Alcohol Research Center, Medical University of South Carolina, Charleston, SC, 29425, USA.ORCID 0000-0003-0780-5971
Audrey E PadulaDepartment of Neuroscience, Charleston Alcohol Research Center, Medical University of South Carolina, Charleston, SC, 29425, USA.
Larry J WilhelmDepartment of Translational Neuroscience, Atrium Health Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Byung ParkDepartment of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.
Kathleen A GrantDepartment of Neurosciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, 97006, USA.ORCID 0000-0002-0380-7219
Betsy M FergusonDepartment of Neurosciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, 97006, USA.ORCID 0000-0002-6992-3538
Rita Cervera-JuanesDepartment of Translational Neuroscience, Atrium Health Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA. rcervera@wakehealth.edu.ORCID 0000-0002-0001-3640
Medical University of South Carolina · USOregon National Primate Research Center · USWake Forest University · USOregon Health & Science University · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Patrick J. Mulholland · 1996 to 2026
$46.8M
Translational measures of risk for excessive alcohol consumptionP60AA010760 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI TAMARA J. PHILLIPS · 2006 to 2026
$34.5M
Stress and Ethanol Self-Administration in MonkeysU01AA013510 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KATHLEEN A GRANT · 2002 to 2026
$11.8M
Monkey Alcohol Tissue Research Resource (MATRR)R24AA019431 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mary Lauren Benton, Verginia Carmella Cuzon Carlson · 2010 to 2026
$10.3M
INIA: Stress, Anxiety of Alcohol AbuseU01AA013641 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GRANT, KATHLEEN A · 2002 to 2015
$8.8M
INIA: Stress, Anxiety and Excessive Alcohol Drinking (Administrative Core)U24AA013641 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KATHLEEN A GRANT · 2016 to 2026
$3.4M
Kv7 channels and heavy alcohol drinkingR01AA023288 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MULHOLLAND, PATRICK J. · 2014 to 2023
$3.4M
Distinguishing preexistent and induced epigenetic risk for alcohol use disordersR01AA026278 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CERVERA JUANES, RITA P · 2019 to 2023
$3.2M
Identifying new targets for the treatment of alcohol dependence and relapse: epigenetic analysis of the abstinent brainR01AA027552 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CERVERA JUANES, RITA P · 2020 to 2024
$2.6M
Stress and Ethanol Dependence: SK Channels and GlutamateU01AA020930 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MULHOLLAND, PATRICK J. · 2012 to 2021
$2.6M
Genetic and Epigenetic Analysis of Alcohol Self-Administration in MonkeysU01AA020928 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI FERGUSON, BETSY M · 2012 to 2016
$1.3M
NIAAA NIH HHS P50 AA010761NIAAA NIH HHS P60 AA010760NIAAA NIH HHS R01 AA023288NIAAA NIH HHS R01 AA026278NIAAA NIH HHS R01 AA027552NIAAA NIH HHS R03 AA026092NIAAA NIH HHS R24 AA019431NIAAA NIH HHS U01 AA013510NIAAA NIH HHS U01 AA013641NIAAA NIH HHS U01 AA020928NIAAA NIH HHS U01 AA020930NIAAA NIH HHS U24 AA013641NIH HHS P51 OD011092
6 · The paper itself

Abstract

The underlying genetic and epigenetic mechanisms driving functional adaptations in neuronal excitability and excessive alcohol intake are poorly understood. Small-conductance Ca

Indexed as

AlcoholismEpigenesis, GeneticSmall-Conductance Calcium-Activated Potassium ChannelsAlcohol DrinkingAnimalsHaplorhiniMiceNucleus AccumbensKcnn3 protein, mouseSmall-Conductance Calcium-Activated Potassium Channels

Identifiers

PMID38012158
PMCPMC10682415
OpenAlexW4389040887

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.